2304-89-4

2304-89-4 structure

Name: 3-Oxocholic acid
Chemical Name: 7α,12α-dihydroxy-3-oxo-5β-cholan-24-oic acid methylester
CAS Number: 2304-89-4
Molecular Formula: C₂₄H₃₈O₅
Molecular Weight: 406.55600
Catalog: Research Areas Metabolic Disease
Create Date: 2018-12-23 13:00:12
Modify Date: 2024-01-12 13:34:58
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals[1][2][3].

Name	7α,12α-dihydroxy-3-oxo-5β-cholan-24-oic acid methylester
Synonyms	3-OXO DEOXYCHOLIC ACID 3-Oxo-7Alpha,12Alpha-hydroxy-5Beta-cholanoic Acid 7Alpha,12Alpha-dihydroxy-3-oxo-5Beta-cholan-24-oic acid 3-Keto-7alpha,12alpha-dihydroxy-5alpha-cholanic acid 3-Oxo-7α,12α-hydroxy-5β-cholanoic Acid 3-Oxo-7a,12a-dihydroxy-5b-cholanic acid

Description	3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals[1][2][3].
Related Catalog	Research Areas >> Metabolic Disease
In Vivo	Male Goto-Kakizaki (GK) rats rats are subjected to Ileal transposition (IT) surgery. In the metabolomics analysis, compared with Sham-IT rats, 3-Oxocholic acid of IT rats is increased[2].
References	[1]. Macdonald I, et al. Identification of 7alpha-, 12alpha-dihydroxy-3-oxo cholanoic acid as the major degradation product from cholic by C. perfringens. J Steroid Biochem. 1978 Apr;9(4):353-8. [2]. Yan K, et al. The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery. Obes Surg. 2019 Mar;29(3):882-890. [3]. Wahlström A, et al. Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. Cell Metab. 2016 Jul 12;24(1):41-50.

Precursor 0
DownStream 3
14772-99-7 14772-92-0 13587-11-6