79617-99-5

• 常用中文名：外消旋盐酸舍曲林
• 常用英文名：4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
• CAS号：79617-99-5
• 分子式：C₁₇H₁₆Cl₃N
• 分子量：340.675
• 发布时间：2018-04-13 08:00:00
• 更新时间：2026-07-18 18:21:52
• 【用途一】
  是舍曲林中间体

名称

• 中文名: 外消旋盐酸舍曲林
• 英文名: 4-(3,4-dichlorophenyl)-N-methyl-3,4-dihydro-2H-naphthalen-1-imine,hydrochloride
• 中文别名: 舍曲林相关化合物A; 4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺盐酸盐; 舍曲林杂质A HCL(RAC-TRANS-舍曲林 HCL); 消旋-反式-舍曲林盐酸盐; 舍曲林相关化合物A盐酸盐; 舍曲林 杂质 A HCL; 舍曲林杂质A /BP); 舍曲林杂质1盐酸盐(舍曲林杂质A盐酸盐); 丝氨酸杂质; 外消旋盐酸舍曲林(舍曲林碱、4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺盐酸盐); 盐酸舍曲林杂质Ⅰ(1R,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-N-甲基-1-萘胺盐酸盐; REL-(1R,4S)-4-(3,4-二氯苯基)-N-甲基-1,2,3,4-四氢萘-1-胺盐酸盐 (舍曲林杂质); 舍曲林杂质A HCL(RAC-TRANS-SERTRALINE HCL); 舍曲林杂质2; 舍曲林碱; 盐酸舍曲林杂质Ⅰ（1R，4S）-4-（3，4-二氯苯基）-1，2，3，4-四氢-N-甲基-1-萘胺盐酸盐; 反式-(1RS,4SR)-异构体; 舍曲林杂质A 盐酸盐; 盐酸舍曲林杂质A盐酸盐; 舍曲林中间体-外消旋盐酸舍曲林
• 英文别名: Sertraline Related Compound A as Hydrochloride; (1S*,2S*)-2-phenylcyclohexanol; (+)-cis-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hyd; Sertralin racemate; rac-trans-Sertraline HCl; 4-(3,4-Dichloro phenyl)-2,3 dihydro 1-(N-Methyl Amino) Naphthaline HCL; 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE; cis-2-phenyl-cyclohexanol; trans-(±)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine Hydrochlo; (1RS,4SR)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine Hydrochloride; (1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride; Sertraline Impurity A (HCL)/Sertraline Impurity A HCL; Sertraline hydrechloride; rel-(1R,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride (Sertraline Impurity); Sertraline Impurity A HCl (rac-trans-Sertraline HCl); 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-naphthalenaminehydrochoide; (1S*,4R*)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine hydrochloride; 2-PHENYL-CYCLOHEXANOL(CIS); cis-2-phenyl-1-cyclohexanol; cis-2-phenylcyclohexan-1-ol; Sertraline Impurity 1 Hydrochloride(Sertraline Impurity A Hydrochloride); trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENIMINECHLORIDE; Sertraline Related Compound II / Sertraline Imp A; (1E)-4-(3,4-Dichlorophenyl)-N-methyl-3,4-dihydro-1(2H)-naphthalenimine hydrochloride (1:1); trans-2-phenylcyclohexanol; Sertraline basis; Sertraline Hydrochloride Impurity Ⅰ：rac-trans-Sertraline Hydrochloride; Sertraline Impurity A HCl (Sertraline Related Compound A, rac-trans-Sertraline HCl); 1R,4S)-rel-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride; MFCD08703316; RACEMIC SERTRALINE HYDROCHLORIDE; 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenimine hydrochloride; Sertraline racemate Hydrochloride; Sertraline Impurity A RC A); Sertraline Impurity 1（Sertraline Impurity A）; SERTRALINE RACEMATE HCl; cis-N-Methyl-4-(3,4-Dichlorophenyl)-tetrahydro-1-naphthalenaminehydrochlorideMIN; Methanamine, N-[(1E)-4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]-, hydrochloride (1:1); Sertraline Hydrochloride Impurity A as Hydrochloride; Sertraline Impurity A HCl; Seraline; 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HCL; cis-N-Methyl-4-(3,4-Dichlorophenyl)-tetrahydro-1-naphthalenamineHClMIN

物化性质

• 沸点: 443.8ºC at 760 mmHg
• 熔点: 275-277ºC
• 分子式: C₁₇H₁₆Cl₃N
• 分子量: 340.675
• 闪点: 222.2ºC
• 精确质量: 339.034821
• PSA: 12.36000
• LogP: 6.14000

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

79836-45-6 ~% 79617-99-5

文献：WO2007/6003 A2, ; Page/Page column 20; 23 ;

上下游产品

上游产品  1
79836-45-6
下游产品  0