79836-45-6

• 常用中文名：RAC-反-舍曲林
• 常用英文名：Rac-trans-Sertraline
• CAS号：79836-45-6
• 分子式：C₁₇H₁₇Cl₂N
• 分子量：306.23000
• 发布时间：2018-04-27 08:00:00
• 更新时间：2026-07-06 17:07:43

名称

• 中文名: RAC-反-舍曲林
• 英文名: (1R,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
• 中文别名: (1R, 4S)-反式盐酸舍曲林; 舍曲林杂质A; 舍曲林欧洲药典杂质 A; (1R,4S) - 反式舍曲林盐酸; (1R,4S)-4-(3,4-二氯苯基)-N-甲基-1,2,3,4-四氢萘-1-胺; 舍曲林杂质A(RAC-反式舍曲林); 外消旋反式舍曲林; (1R.4S)-反式盐酸舍曲林
• 英文别名: rac-trans-(1S,4R)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalene; Sertraline Impurity-A (Trans sertraline); Sertraline,(1RS,4SR); Sertraline Impurity A(rac-trans-Sertraline); 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1R,4S)-rel; "(1R, 4S)-trans-Sertraline Hydrochloride"; racemic sertraline; UNII-4N6S45X78A; cis-racemate; Sertraline trans isomer racemic mixture; Sertraline,trans-(+/-); (1R,4S)-trans-Sertraline; (+/-)-trans-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; rac trans Sertraline; (rac)-trans-sertraline; (1R,4S)-Trans-Sertraline; (1R, 4S)-trans-Sertraline HCl; trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine; (1R,4S)-rel-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; (1R,4S)-rel; trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; trans-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

物化性质

• 密度: 1.255g/cm3
• 沸点: 416.33ºC at 760 mmHg
• 分子式: C₁₇H₁₇Cl₂N
• 分子量: 306.23000
• 闪点: 205.589ºC
• 精确质量: 305.07400
• PSA: 12.03000
• LogP: 5.57050
• 折射率: 1.621

合成路线

6284-79-3 ~% 79836-45-6

文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

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文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

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文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

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文献：Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515

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文献：Organic Process Research and Development, , vol. 8, # 3 p. 385 - 388

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文献：Organic Process Research and Development, , vol. 8, # 3 p. 385 - 388

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