1852-36-4

• 常用中文名：Cortisol sulfate sodium
• 常用英文名：Cortisol sulfate sodium
• CAS号：1852-36-4
• 分子式：C₂₁H₂₉NaO₈S
• 分子量：464.50
• 相关类别： 研究领域 内分泌
• 发布时间：2017-06-10 12:57:31
• 更新时间：2024-01-12 10:23:03
• 硫酸皮质醇钠(硫酸皮质醇21)是皮质醇(HY-N0583)的代谢产物。皮质醇硫酸钠是细胞内转铁蛋白的特异配体[1][2][3]。

名称

• 英文名: hydrocortisone 21-(sodium sulphate)
• 英文别名: Corticosterone acetate; 4-Pregnene-11beta,21-diol-3,20-dione 21-acetate; Cort A; 11beta,21-Dihydroxy-4-pregnene-3,20-dione 21-acetate; 2-((8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; Hydrocortisone-21-sulfatesodium; Cortisol-21-sulfat; 11beta,21-Dihydroxypregn-4-ene-3,20-dione 21-acetate; Corticosterone 21-acetate

物化性质

• 分子式: C₂₁H₂₉NaO₈S
• 分子量: 464.50
• 精确质量: 464.14800
• PSA: 149.41000
• LogP: 2.34690

生物活性

• 描述: 硫酸皮质醇钠(硫酸皮质醇21)是皮质醇(HY-N0583)的代谢产物。皮质醇硫酸钠是细胞内转铁蛋白的特异配体[1][2][3]。
• 相关类别:
  研究领域 >> 内分泌
• 体内研究: 皮质醇硫酸钠(3 mg；i.m.；每隔一天；持续2-7周)通过其对中枢神经系统的直接作用影响行为[4]。
• 参考文献:

  [1]. C S Hall, et al. Simultaneous metabolism of cortisol sulfate and cortisol in normal human adults. J Clin Endocrinol Metab. 1970 Oct;31(4):439-44.

  [2]. S S Singer, et al. Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations. Endocrinology. 1976 Apr;98(4):963-74.

  [3]. T Hayashi, et al. Cortisol-21-sulfate (FS) is a specific ligand for intracellular transcortin: demonstration of three types of high affinity corticosteroid binders in bovine aortic cytosol by a combined use of FS and RU 28362. Endocrinology. 1990 Jan;126(1):307-16.

  [4]. S Miyabo, et al. Behavioral and other systemic effects of cortisol-21 sulfate. Horm Behav. 1972 Sep;3(3):227-36.