314-19-2

314-19-2结构式

常用中文名：盐酸去水吗啡
常用英文名：A 922500
CAS号：314-19-2
分子式：C₁₇H₁₈ClNO₂
分子量：303.783
相关类别：原料药消化系统用药止吐催吐药
发布时间：2018-07-14 18:51:24
更新时间：2026-07-27 15:23:58
Apomorphine Hydrochloride, also known as APL-130277 and TAK-251, is a dopamine D2 agonist used for the treatment of Parkinson's disease. Apomorphine also promotes intraneuronal amyloid-β (Aβ) degradation and improves memory function in an Alzheimer's disease model. Protein levels of two types of serine-phosphorylated insulin receptor substrate-1 (IRS-1), pS616 and pS636/639, significantly decreased following Apomorphine treatment in the 13-month-old 3xTg-AD mice brain, suggesting improved brain insulin resistance.

化源商城直购

中文名	R-(-)-阿朴吗啡盐酸盐
英文名	(R)-(-)-Apomorphine hydrochloride,(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diolhydrochloride
中文别名	變嗎啡鹼鹽酸鹽 R(-)-阿扑吗啡盐酸盐盐酸去水吗啡(阿扑吗啡盐酸盐、盐酸阿朴吗啡、R-(-)-阿朴吗啡盐酸盐、啡酸、R(–)-10,11-二羟基阿朴啡) R(–)-10,11-二羟基阿朴啡盐酸阿扑吗啡盐酸阿朴吗啡烟酸阿朴吗啡阿扑吗啡【禁售】(R)-(-)-APOMORPHINE HYDROCHLORIDE 化合物()-Apomorphine (hydrochloride) 啡酸
英文别名	apomorphine HCl g)quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(dhydrochlor R(-)-10,11-DIHYDROXYAPORPHINE HYDROCHLORIDE (-)-apomorphiniumhydrochloride 6aβ-Aporphine-10,11-diol, hydrochloride (8CI) apomorphinechloride APL-130277 EINECS 206-243-0 (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride 4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (6) Apomorphinhydrochlorid 4H-dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-, hydrochloride Apomorphine hydrochoride R(–)-APO (-)-apomorphine hydrochloride (r)-id (theta)-id Apomorphine HydrochlorideQ: What is Apomorphine Hydrochloride Q: What is the CAS Number of Apomorphine Hydrochloride Q: What is the storage condition of Apomorphine Hydrochloride Q: What e the applications of Apomorphine Hydrochloride 6a-beta-aporphine-10,11-diol,hydrochloride (6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride (1:1) g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[dhydrochlor 6-Methyl-6ab-noraporphine-10,11-diol Hydrochloride (-)-APO H CL APL130277 Apomorphine HCl (APL130277 APOMORPHINE HYDROCHLORIDE 6aβ-Noraporphine-10,11-diol, 6-methyl-, hydrochloride R-Apomorphine hydrochloride,R(–)-10,11-Dihydroxyaporphine, R(–)-APO 6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-, hydrochloride (1:1) (6aR)-6-méthyl-5,6,6a,7-tétrahydro-4H-dibenzo[de,g]quinoléine-10,11-diol chlorhydrate 11-diol,6-methyl-6a-beta-noraporphine-1hydrochloride (6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]chinolin-10,11-diolhydrochlorid APOMORPHINE HYDROCHLORIDE //BP ()-Apomorphine 6aβ-Aporphine-10,11-diol, hydrochloride Apomorphine.HCl, 1mg/ml in Methanol (as free base) apomorphiniumchloride TAK251) g)quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(dhydr APOMORPHINE HCL (R)-(-)-APOMORPHINE HYDROCHLORIDE KW-6500 (R)-5,6,6A,7-TETRAHYDRO-6-METHYL-4H-DIBENZO[DE,G]QUINOLINE-10,11-DIOL HYDROCHLORIDE 6ab-Aporphine-10,11-diol Hydrochloride UPRIMA

沸点	473.4ºC at 760mmHg
熔点	195ºC (decomposes)
分子式	C₁₇H₁₈ClNO₂
分子量	303.783
闪点	268.8ºC
精确质量	303.102600
PSA	43.70000
LogP	3.58980
储存条件	库房通风低温干燥,与食品原料分开存放
分子结构	1、摩尔折射率：77.86 2、摩尔体积（m³/mol）：205.6 3、等张比容（90.2K）：568.1 4、表面张力（dyne/cm）：58.2 5、极化率（10 ^-24cm ³）：30.86
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:3 3.氢键受体数量:3 4.可旋转化学键数量:0 5.互变异构体数量:18 6.拓扑分子极性表面积43.7 7.重原子数量:21 8.表面电荷:0 9.复杂度:374 10.同位素原子数量:0 11.确定原子立构中心数量:1 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2
更多	一、物性数据性状：不可用密度（g/mL,25/4℃）：不可用相对蒸汽密度（g/mL,空气=1）：不可用熔点（ºC）：不可用沸点（ºC,常压）：不可用沸点（ºC,5.2kPa）：不可用折射率：不可用闪点（ºC）：不可用比旋光度（º）：不可用自燃点或引燃温度（ºC）：不可用蒸气压（kPa,25ºC）：不可用饱和蒸气压（kPa,60ºC）：不可用燃烧热（KJ/mol）：不可用临界温度（ºC）：不可用临界压力（KPa）：不可用油水（辛醇/水）分配系数的对数值：不可用爆炸上限（%,V/V）：不可用爆炸下限（%,V/V）：不可用溶解性：不可用

毒理学数据:

二、毒理学数据：

急性毒性：不可用。

生态学数据:

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ1750000

CHEMICAL NAME :: 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 314-19-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H17-N-O2.Cl-H

MOLECULAR WEIGHT :: 303.81

WISWESSER LINE NOTATION :: T C6666 1A Q KN&TT&J DQ EQ K1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 137,17,1984