DC Chemicals Limited
China
Product Name: Apomorphine Hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Apomorphine Hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

314-19-2

314-19-2 structure

Name: A 922500
Chemical Name: (R)-(-)-Apomorphine hydrochloride,(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diolhydrochloride
CAS Number: 314-19-2
Molecular Formula: C₁₇H₁₈ClNO₂
Molecular Weight: 303.783
Catalog: API Digestive system medication Antiemetic emetic
Create Date: 2018-07-14 18:51:24
Modify Date: 2024-01-03 17:40:06
Apomorphine Hydrochloride, also known as APL-130277 and TAK-251, is a dopamine D2 agonist used for the treatment of Parkinson's disease. Apomorphine also promotes intraneuronal amyloid-β (Aβ) degradation and improves memory function in an Alzheimer's disease model. Protein levels of two types of serine-phosphorylated insulin receptor substrate-1 (IRS-1), pS616 and pS636/639, significantly decreased following Apomorphine treatment in the 13-month-old 3xTg-AD mice brain, suggesting improved brain insulin resistance.

Name	(R)-(-)-Apomorphine hydrochloride,(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diolhydrochloride
Synonyms	6aβ-Noraporphine-10,11-diol, 6-methyl-, hydrochloride apomorphine HCl 6aβ-Aporphine-10,11-diol, hydrochloride (8CI) apomorphinechloride EINECS 206-243-0 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-, hydrochloride (1:1) (6aR)-6-méthyl-5,6,6a,7-tétrahydro-4H-dibenzo[de,g]quinoléine-10,11-diol chlorhydrate (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride 4H-dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (6aR)-, hydrochloride Apomorphine hydrochoride (-)-apomorphine hydrochloride (6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]chinolin-10,11-diolhydrochlorid (6aR)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride (1:1) 6aβ-Aporphine-10,11-diol, hydrochloride apomorphiniumchloride 6-Methyl-6ab-noraporphine-10,11-diol Hydrochloride 6ab-Aporphine-10,11-diol Hydrochloride APOMORPHINE HYDROCHLORIDE UPRIMA

Boiling Point	473.4ºC at 760mmHg
Melting Point	195ºC (decomposes)
Molecular Formula	C₁₇H₁₈ClNO₂
Molecular Weight	303.783
Flash Point	268.8ºC
Exact Mass	303.102600
PSA	43.70000
LogP	3.58980

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ1750000

CHEMICAL NAME :: 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, (R)-

CAS REGISTRY NUMBER :: 314-19-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H17-N-O2.Cl-H

MOLECULAR WEIGHT :: 303.81

WISWESSER LINE NOTATION :: T C6666 1A Q KN&TT&J DQ EQ K1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 137,17,1984

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)

86709-01-5

314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

86680-37-7

314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

86680-39-9

314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

467-14-1

314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

58-00-4

314-19-2

Literature: WO2009/38958 A1, ; Page/Page column 5 ;

86545-92-8

314-19-2

Literature: Acta Chimica Hungarica, , vol. 113, # 1 p. 51 - 60

Precursor 6
86709-01-5 86680-37-7 86680-39-9 467-14-1
58-00-4 86545-92-8
DownStream 1
18605-43-1

314-19-2	959122-11-3
62653-92-3	60753-49-3
67300-99-6	52790-57-5
100149-43-7	23819-31-0
27129-86-8	1044189-20-9
1158522-08-7	940364-43-2
134104-43-1	1775554-68-1
131615-57-1	6906-52-1
2098144-21-7	2034893-76-8
930439-75-1	1018584-77-4