96206-92-7

• 常用中文名：2-甲基-6-(苯基乙炔基)吡啶
• 常用英文名：MPEP
• CAS号：96206-92-7
• 分子式：C₁₄H₁₁N
• 分子量：193.24
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) GluR 拮抗剂
• 发布时间：2018-12-31 15:55:30
• 更新时间：2024-01-05 19:48:47
• MPEP是mGlu5受体非竞争性拮抗剂，IC50为36 nM，还是mGlu4受体的正向变构调节剂。

名称

• 中文名: 2-甲基-6-(苯乙炔)吡啶盐酸盐
• 英文名: MPEP hydrochloride,2-Methyl-6-(phenylethynyl)pyridinehydrochloride
• 中文别名: 2-甲基-6-(苯基乙炔基)吡啶; 2-甲基-6-(2-苯乙炔)-吡啶; 盐酸夫拉平度
• 英文别名: 2-Methyl-6-(phenylethynyl)pyridine hydrochloride; MPEP,HCl; MFCD02262119; Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1); MPEP; 2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1); 2-methyl-6-phenylethynyl-pyridine; 2-Methyl-6-phenylaethinyl-pyridin

物化性质

• 沸点: 336.3ºC at 760mmHg
• 分子式: C₁₄H₁₁N
• 分子量: 193.24
• 闪点: 144.8ºC
• PSA: 12.89000
• LogP: 3.59180
• 储存条件: Desiccate at +4°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:3.3

  2.氢键供体数量:0

  3.氢键受体数量:1

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积12.9

  7.重原子数量:15

  8.表面电荷:0

  9.复杂度:251

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: MPEP是mGlu5受体非竞争性拮抗剂,IC50为36 nM,还是mGlu4受体的正向变构调节剂。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

  [2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.

  [3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

安全

• 海关编码: 2933399090

合成路线

5315-25-3 2170-06-1 ~50% 96206-92-7

文献：Sorensen, Ulrik S.; Pombo-Villar, Esteban Tetrahedron, 2005 , vol. 61, # 10 p. 2697 - 2703

5315-25-3 536-74-3 ~88% 96206-92-7

文献：Saleh, Samer; Picquet, Michel; Meunier, Philippe; Hierso, Jean-Cyrille Synlett, 2011 , # 19 art. no. D22511ST, p. 2844 - 2848

5315-25-3 637-44-5 ~72% 96206-92-7

文献：Reddy, Police Vishnuvardhan; Srinivas, Pottabathula; Annapurna, Manne; Bhargava, Suresh; Wagler, Jorg; Mirzadeh, Nedaossadat; Kantam, Mannepalli Lakshmi Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 705 - 710

591-50-4 656800-40-7 ~% 96206-92-7

文献：Jaeschke, Georg; Porter, Richard; Buettelmann, Bernd; Ceccarelli, Simona M.; Guba, Wolfgang; Kuhn, Bernd; Kolczewski, Sabine; Huwyler, Joerg; Mutel, Vincent; Peters, Jens-Uwe; Ballard, Theresa; Prinssen, Eric; Vieira, Eric; Wichmann, Juergen; Spooren, Will Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1307 - 1311

931-19-1 ~% 96206-92-7 66310-15-4

文献：Nishiwaki, Nagatoshi; Minakata, Satoshi; Komatsu, Mitsuo; Ohshiro, Yoshiki Chemistry Letters, 1989 , p. 773 - 776

上下游产品

上游产品  7
5315-25-3 2170-06-1 536-74-3 637-44-5
591-50-4 656800-40-7 931-19-1
下游产品  1
1083-25-6

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%