96206-92-7

96206-92-7 structure

Name: MPEP
Chemical Name: MPEP hydrochloride,2-Methyl-6-(phenylethynyl)pyridinehydrochloride
CAS Number: 96206-92-7
Molecular Formula: C₁₄H₁₁N
Molecular Weight: 193.24
Catalog: Biochemical Inhibitor Neuronal Signaling GluR antagonist
Create Date: 2018-12-31 15:55:30
Modify Date: 2024-01-05 19:48:47
MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. IC50 value: 36 nMTarget: mGluR5Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Name	MPEP hydrochloride,2-Methyl-6-(phenylethynyl)pyridinehydrochloride
Synonyms	2-Methyl-6-(phenylethynyl)pyridine hydrochloride MPEP,HCl MFCD02262119 Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1) MPEP 2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1) 2-methyl-6-phenylethynyl-pyridine 2-Methyl-6-phenylaethinyl-pyridin

Description	MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. IC50 value: 36 nMTarget: mGluR5Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Related Catalog	Research Areas >> Neurological Disease
References	[1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. [2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599. [3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

Boiling Point	336.3ºC at 760mmHg
Molecular Formula	C₁₄H₁₁N
Molecular Weight	193.24
Flash Point	144.8ºC
PSA	12.89000
LogP	3.59180
Storage condition	Desiccate at +4°C

HS Code	2933399090

5315-25-3

2170-06-1

~50%

96206-92-7

Literature: Sorensen, Ulrik S.; Pombo-Villar, Esteban Tetrahedron, 2005 , vol. 61, # 10 p. 2697 - 2703

5315-25-3

536-74-3

~88%

96206-92-7

Literature: Saleh, Samer; Picquet, Michel; Meunier, Philippe; Hierso, Jean-Cyrille Synlett, 2011 , # 19 art. no. D22511ST, p. 2844 - 2848

5315-25-3

637-44-5

~72%

96206-92-7

Literature: Reddy, Police Vishnuvardhan; Srinivas, Pottabathula; Annapurna, Manne; Bhargava, Suresh; Wagler, Jorg; Mirzadeh, Nedaossadat; Kantam, Mannepalli Lakshmi Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 705 - 710

591-50-4

656800-40-7

96206-92-7

Literature: Jaeschke, Georg; Porter, Richard; Buettelmann, Bernd; Ceccarelli, Simona M.; Guba, Wolfgang; Kuhn, Bernd; Kolczewski, Sabine; Huwyler, Joerg; Mutel, Vincent; Peters, Jens-Uwe; Ballard, Theresa; Prinssen, Eric; Vieira, Eric; Wichmann, Juergen; Spooren, Will Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1307 - 1311

931-19-1

96206-92-7

66310-15-4

Literature: Nishiwaki, Nagatoshi; Minakata, Satoshi; Komatsu, Mitsuo; Ohshiro, Yoshiki Chemistry Letters, 1989 , p. 773 - 776

Precursor 7
5315-25-3 2170-06-1 536-74-3 637-44-5
591-50-4 656800-40-7 931-19-1
DownStream 1
1083-25-6

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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