941685-26-3

• 常用中文名：4-氯-7-[[2-(三甲基硅烷基)乙氧基]甲基]-7H-吡咯并[2,3-d]嘧啶
• 常用英文名：4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS号：941685-26-3
• 分子式：C₁₂H₁₈ClN₃OSi
• 分子量：283.829
• 发布时间：2018-12-28 11:29:45
• 更新时间：2026-07-18 09:52:33

名称

• 中文名: 4-氯-7-((2-(三甲基硅烷基)乙氧基)甲基)-7H-吡咯并(2,3-d)嘧啶
• 英文名: 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
• 中文别名: 4-氯-7-[[2-(三甲基硅烷基)乙氧基]甲基]-7H-吡咯并[2,3-D]嘧啶; 5-氯-7-{[2-(三甲基甲硅烷基)乙氧基]甲基}-7H-吡咯并[2,3-D]嘧啶; 4-氯-7-((2-(三甲基甲硅烷基)乙氧基)甲基)-7H-吡咯并[2,3-D]…; 巴瑞克替尼杂质72; 4-氯-7 - ((2-(三甲基硅基)乙氧基)甲基)-7H-吡咯并[2,3-D]嘧啶; 巴瑞替尼杂质4; 巴利替尼杂质9; 巴瑞克替尼中间体5; 巴瑞替尼杂质72; 4-氯-7-((2-(三甲基甲硅烷基)乙氧基)甲基)-7H-吡咯并[2,3-D]嘧啶
• 英文别名: 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrolo[2,3-D]pyrimidine; Ruxolitinib SEM Chloro pyrimidine; 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl-7H-pyrrolo[2,3; Bitinib impurity 9; 2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethylsilane; 2-[(4-CHLOROPYRROLO[2,3-D]PYRIMIDIN-7-YL)METHOXY]ETHYL-TRIMETHYLSILANE; 7H-Pyrrolo[2,3-d]pyriMidine, 4-chloro-7-[[2-(triMethylsilyl)ethoxy]Methyl]; 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE; Bicitinib Impurity 72; 7-((2-(triMethylsilyl)ethoxy)Methyl)-4-chloro-7H-pyrrolo[2,3-d]pyriMidine; 4-Chloro-7-[[2-(trimethylsilanyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 368.3±37.0 °C at 760 mmHg
• 分子式: C₁₂H₁₈ClN₃OSi
• 分子量: 283.829
• 闪点: 176.6±26.5 °C
• 精确质量: 283.090759
• PSA: 39.94000
• LogP: 3.13
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.554
• 储存条件: 室温

合成路线

76513-69-4 3680-69-1 ~90% 941685-26-3

文献：Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng Patent: US2010/190981 A1, 2010 ; Location in patent: Page/Page column 73 ; US 20100190981 A1

7400-06-8 ~% 941685-26-3

文献：Bioorganic and Medicinal Chemistry, , vol. 20, # 22 p. 6770 - 6789

3680-71-5 ~% 941685-26-3

文献：Bioorganic and Medicinal Chemistry, , vol. 20, # 22 p. 6770 - 6789

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941685-27-4