941685-27-4

• 常用中文名：4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶 (巴瑞克替尼中间体)
• 常用英文名：INCB032304
• CAS号：941685-27-4
• 分子式：C₁₅H₂₁N₅OSi
• 分子量：315.45
• 发布时间：2018-12-27 19:39:49
• 更新时间：2026-07-16 16:07:45
• 4-(1H-吡唑-4-基)-7-[[2-(三甲基甲硅烷基)乙氧基]甲基]-7H-吡咯并[2,3-d]嘧啶是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

名称

• 中文名: 4-(1H-吡唑-4-基)-7-((2-(三甲基甲硅烷基)乙氧基)-甲基)-7h-吡咯并[2,3-d]嘧啶
• 英文名: trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
• 中文别名: 抑制剂4-(4-Pyrazolyl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine; 4-(1H-吡唑-4-基)-7-((2-(三甲基甲硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-d]嘧啶(巴瑞克替尼中间体); 鲁索替尼杂质10; 4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶,巴瑞替尼中间体; 4-(1H-吡唑-4-基)-7 - ((2-(三甲基硅基)乙氧基)甲基)-7H-吡咯并[2,3-D]嘧啶; 4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]; 巴瑞克替尼中间体; 4-(4-吡唑基)-7-[[2-(三甲基硅基)乙氧基]甲基]-7H-吡咯并[2,3-D]嘧啶; 巴瑞克替尼中间体7; 巴瑞替尼杂质N2; 巴瑞克替尼中间体4-(1H-吡唑-4-基)-7-((2-(三甲基甲硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶; 4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基); 4-(1H-吡唑-4-基)-7-((2-(三甲基甲硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶; 4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶 巴瑞克替尼中间体; 4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡…; 4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶
• 英文别名: INCB032304, 10 mM in DMSO; 7-((2-(trimethylsilyl); 4-(1H-pyrazol-4-yl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-(4-Pyrazolyl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine; 4-(1H-PYRAZOL-4-YL)-7-((2-(TRIMETHYLSILYL)ETHOXY)-METHYL)-7H -PYRROLO[2,3-D]PYRIMIDINE; rimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane; 4(1H-pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolol[2,3-d]pyrimidine; RROLO[2,3-D]PYRIMIDINE; Bretinib Intermediate 1; 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; (1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; Bicitinib Impurity N2; 4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole; 4-(1H-Pyrazol-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine; 4-(1H-PYRAZOL-4-YL)-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE; 4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]p; 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidineQ: What is 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Q: What is the CAS Number of 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Q: What is the storage condition of 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl-7H-p; 4- (1H pyrazole-4-yl) -7- (2- (trimethylsilyl) ethoxy) - methyl) -7H pyrrolo [2,3-d] pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 4-(1H-pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]; 4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 501.8±50.0 °C at 760 mmHg
• 分子式: C₁₅H₂₁N₅OSi
• 分子量: 315.45
• 闪点: 257.3±30.1 °C
• 精确质量: 315.151550
• PSA: 68.62000
• LogP: 2.45
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.607
• 储存条件: 室温，干燥

生物活性

• 描述: 4-(1H-吡唑-4-基)-7-[[2-(三甲基甲硅烷基)乙氧基]甲基]-7H-吡咯并[2,3-d]嘧啶是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

合成路线

269410-08-4 941685-26-3 ~64% 941685-27-4

文献：Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng Patent: US2010/190981 A1, 2010 ; Location in patent: Page/Page column 75-76 ; US 20100190981 A1

941685-41-2 ~87% 941685-27-4

文献：Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng Patent: US2010/190981 A1, 2010 ; Location in patent: Page/Page column 84-85 ; US 20100190981 A1

941685-26-3 1029716-44-6 ~% 941685-27-4

文献：US2011/224190 A1, ; Page/Page column 37-38 ; US 20110224190 A1

1187595-88-5 ~% 941685-27-4

文献：Lin, Qiyan; Meloni, David; Pan, Yongchun; Xia, Michael; Rodgers, James; Shepard, Stacey; Li, Mei; Galya, Laurine; Metcalf, Brian; Yue, Tai-N; Liu, Pingli; Zhou, Jiacheng Organic Letters, 2009 , vol. 11, # 9 p. 1999 - 2002

76513-69-4 ~% 941685-27-4

文献：US2011/224190 A1, ; US 20110224190 A1

3680-69-1 ~% 941685-27-4

文献：US2011/224190 A1, ; US 20110224190 A1

941685-26-3 ~% 941685-27-4

文献：WO2013/36611 A1, ;

上下游产品

上游产品  5
269410-08-4 941685-26-3 1029716-44-6 76513-69-4
3680-69-1
下游产品  3
1092939-15-5 941678-49-5 1092939-17-7

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%