5884-22-0

• 常用中文名：1-(34-二甲氧基苄基)-67-二甲氧基-34-二氢异喹啉盐酸盐
• 常用英文名：1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride
• CAS号：5884-22-0
• 分子式：C₂₀H₂₄ClNO₄
• 分子量：377.862
• 发布时间：2018-04-16 08:00:00
• 更新时间：2024-01-14 11:12:55

名称

• 中文名: 二氢罂粟碱盐酸盐
• 英文名: 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride
• 中文别名: 6,7-二甲氧基-1-(3,4-二甲氧基苄基)-3,4-二氢异喹啉盐酸盐
• 英文别名: 6,7-Dimethoxy-1-veratryl-3,4-dihydro-isochinolin,Hydrochlorid; DIHYDROALKALI HYDROCHLORIDE; isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-, hydrochloride (1:1); Isoquinolinium, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-, chloride (1:1); 3,4-dihydropapaverine hydrochloride; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium chloride; Dihydropapaverinehydrochloride; 6,7-dimethoxy-1-veratryl-3,4-dihydro-isoquinoline,hydrochloride

物化性质

• 沸点: 482.6ºC at 760mmHg
• 熔点: 202ºC
• 分子式: C₂₀H₂₄ClNO₄
• 分子量: 377.862
• 闪点: 196.9ºC
• 精确质量: 377.139374
• PSA: 49.28000
• LogP: 3.54650
• 折射率: 1.554
• 储存条件: 室温

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NW7628980 CHEMICAL NAME : Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-veratryl-, hydrochloride CAS REGISTRY NUMBER : 5884-22-0 LAST UPDATED : 198609 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C20-H23-N-O4.Cl-H MOLECULAR WEIGHT : 377.90 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : APPBDI Acta Physiologica et Pharmacologica Bulgarica. (Izdatelstvo na Bulgarskata Akademiya na Naukite, ul. Akad. G. Bonchev, 1113 Sofia, Bulgaria) V.1- 1974- Volume(issue)/page/year: 5(3),82,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 5,69,1950

安全

• 海关编码: 2933499090

合成路线

139-76-4 ~96% 5884-22-0

文献：Shen, Li; Yang, Xiaochun; Yang, Bo; He, Qiaojun; Hu, Yongzhou European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 11 - 18

102011-15-4 ~% 5884-22-0

文献：Stenlake; Waigh; Urwin; et al. European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 503 - 507

93-40-3 ~% 5884-22-0

文献：Actelion Pharmaceuticals Ltd. Patent: EP2402322 A1, 2012 ;

120-20-7 ~% 5884-22-0

文献：Stenlake; Waigh; Urwin; et al. European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 503 - 507

上下游产品

上游产品  4
139-76-4 102011-15-4 120-20-7 93-40-3
下游产品  1
13074-31-2

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%