5884-22-0

5884-22-0 structure
5884-22-0 structure

Name 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride
Synonyms 6,7-Dimethoxy-1-veratryl-3,4-dihydro-isochinolin,Hydrochlorid
DIHYDROALKALI HYDROCHLORIDE
isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-, hydrochloride (1:1)
Isoquinolinium, 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-, chloride (1:1)
3,4-dihydropapaverine hydrochloride
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium chloride
Dihydropapaverinehydrochloride
6,7-dimethoxy-1-veratryl-3,4-dihydro-isoquinoline,hydrochloride
Boiling Point 482.6ºC at 760mmHg
Melting Point 202ºC
Molecular Formula C20H24ClNO4
Molecular Weight 377.862
Flash Point 196.9ºC
Exact Mass 377.139374
PSA 49.28000
LogP 3.54650
Index of Refraction 1.554

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW7628980
CHEMICAL NAME :
Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-veratryl-, hydrochloride
CAS REGISTRY NUMBER :
5884-22-0
LAST UPDATED :
198609
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H23-N-O4.Cl-H
MOLECULAR WEIGHT :
377.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APPBDI Acta Physiologica et Pharmacologica Bulgarica. (Izdatelstvo na Bulgarskata Akademiya na Naukite, ul. Akad. G. Bonchev, 1113 Sofia, Bulgaria) V.1- 1974- Volume(issue)/page/year: 5(3),82,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 5,69,1950
HS Code 2933499090

~96%

5884-22-0 structure

5884-22-0

Literature: Shen, Li; Yang, Xiaochun; Yang, Bo; He, Qiaojun; Hu, Yongzhou European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 11 - 18

~%

5884-22-0 structure

5884-22-0

Literature: Stenlake; Waigh; Urwin; et al. European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 503 - 507

~%

5884-22-0 structure

5884-22-0

Literature: Actelion Pharmaceuticals Ltd. Patent: EP2402322 A1, 2012 ;

~%

5884-22-0 structure

5884-22-0

Literature: Stenlake; Waigh; Urwin; et al. European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 503 - 507
HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%