314-35-2

• 常用中文名：7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
• 常用英文名：7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
• CAS号：314-35-2
• 分子式：C₁₃H₂₁N₅O₂
• 分子量：279.33800
• 发布时间：2017-07-24 04:12:38
• 更新时间：2024-01-08 23:42:36

名称

• 英文名: 7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
• 英文别名: Ditenate; ETAFEDRINE; 2-[ethyl(methyl)amino]-1-phenylpropan-1-ol hydrochloride(1:1); Etafedrine HCl; Etafedrine hydrochloride [USAN]; 7-(2-Diaethylamino-aethyl)-1,3-dimethyl-3,7-dihydro-purin-2,6-dion; 2-N-ethyl-N-methylamino-1-phenylpropanol hydrochloride; 7-(2-diethylamino-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; Etafedrine hydrochloride; etamiphylline; Nethamine; Nethamine (TN); Soluphylline; 7-[2-(diethylamino)ethyl]theophylline; Etafedrinhydrochlorid

物化性质

• 密度: 1.24g/cm3
• 沸点: 460.2ºC at 760mmHg
• 分子式: C₁₃H₂₁N₅O₂
• 分子量: 279.33800
• 闪点: 232.1ºC
• 精确质量: 279.17000
• PSA: 65.06000
• 折射率: 1.605

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XH5095000 CHEMICAL NAME : Theophylline, 7-(2-diethylamino)ethyl- CAS REGISTRY NUMBER : 314-35-2 BEILSTEIN REFERENCE NO. : 0291098 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C13-H21-N5-O2 MOLECULAR WEIGHT : 279.39 WISWESSER LINE NOTATION : T56 BN DN FNVNVJ B2N2&2 F1 H1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - olfactory nerve change Behavioral - convulsions or effect on seizure threshold Cardiac - change in rate REFERENCE : HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 9,201,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1237 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 254 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 182 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,649,1954

安全

• 海关编码: 2933990090

合成路线

58-55-9 100-35-6 ~82% 314-35-2

文献：Bram; Bensaid; Combet-Farnoux; et al. Pharmazie, 1986 , vol. 41, # 6 p. 431 - 432

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上游产品  2
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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%