CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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MA4900000
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CHEMICAL NAME :
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Glutarimide, 3-(2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexy l)ethyl)-, (-)-
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CAS REGISTRY NUMBER :
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523-86-4
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LAST UPDATED :
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199109
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C15-H23-N-O5
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MOLECULAR WEIGHT :
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297.39
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WISWESSER LINE NOTATION :
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T6VMVTJ EYQ1- BL6VTJ DQ D1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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920 ug/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 136,400,1962
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3952 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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6500 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 30,9,1963
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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11 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971
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