26471-62-5

26471-62-5结构式

常用中文名：甲苯二异氰酸酯
常用英文名：Tolylene diisocyanate
CAS号：26471-62-5
分子式：C₉H₆N₂O₂
分子量：174.156
相关类别：有机原料羧酸类化合物及衍生物羧酸酯及其衍生物
发布时间：2018-02-05 08:00:00
更新时间：2024-01-05 09:53:46
用于制造聚氨酯泡沫塑料及橡胶、绝缘漆及粘合剂等

中文名	甲苯二异氰酸酯
英文名	toluene diisocyanate
中文别名	二异氰酸甲苯 1,3-二异氰酸基甲苯
英文别名	2,6-Toluene diisocyanate 2,4-diisocyanatotoluene EINECS 247-722-4 2,6-Toluene diisocyanate,mixture of 20 percent,mixture of 80 percent,diisocyanatotoluene Tolylene Diisocyanate 2,4-toluene diisocyanate,80 percent,2,6-toluene diisocyanate,20 percent,mixture of Tolylene Diisocyanate,2,4 MFCD01778251 2,4-Toluene diisocyanate 2,4-Sulfonitrophenol NV 2,4-toluene diisocyanate,2,6-toluene diisocyanate,mixture of Toluene Diisocyanate

密度	1.1±0.1 g/cm3
沸点	248.4±0.0 °C at 760 mmHg
熔点	19.5-21.5ºC
分子式	C₉H₆N₂O₂
分子量	174.156
闪点	110.5±29.3 °C
精确质量	174.042923
PSA	58.86000
LogP	3.47
外观性状	透明无色至淡黄色液体
蒸汽压	0.0±0.5 mmHg at 25°C
折射率	1.559
储存条件	库房通风低温干燥,与食品原料分开储运
稳定性	本品有毒，对人的眼睛黏膜和呼吸系统有强烈的刺激作用，与皮肤接触能引起发痒和脱皮。还能破坏人体的蛋白质。
水溶解性	混溶：乙醚,苯,丙酮
分子结构	1、摩尔折射率：49.28 2、摩尔体积（cm³/mol）：152.8 3、等张比容（90.2K）：397.8 4、表面张力（dyne/cm）：45.8 5、极化率（10^-24cm³）：19.53
计算化学	1、疏水参数计算参考值（XlogP）：3.9 2、氢键供体数量：0 3、氢键受体数量：4 4、可旋转化学键数量：2 5、拓扑分子极性表面积（TPSA）：58.9 6、重原子数：13 7、表面电荷：0 8、复杂度：265 9、同位素原子数量：0 10、确定原子立构中心数量：0 11、不确定原子立构中心数量：0 12、确定化学键立构中心数量：0 13、不确定化学键立构中心数量：0 14、共价键单元数量：1
更多	1. 性状：无色至淡黄色液体，有强烈刺激气味。 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC）：251 6. 沸点（ºC，2000Pa）：125 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：溶于乙醚、丙酮和其他有机溶剂。

国标编号:
ＣＡＳ:	26471-62-5
中文名称:	甲苯二异氰酸酯
英文名称:	Toluene diisocyanate
别名:	二异氰酸甲苯酯;Diisocyanatotoluene;TDI;
分子式:	C₉H₆N₂O₂
分子量:	174.16
熔点:	3.5～5.5 ℃(TDI-65);
密度:	1.22±0.01(25℃)
蒸汽压:	132℃(闭杯)
溶解性:	不溶于水; 溶于丙酮、乙酸乙酯和甲苯等
稳定性:	能与强氧化剂发生反应。遇热、明火、火花会着火
外观与性状:	无色透明至淡黄色液体,有刺激性气味
危险标记:
用途:	用于制造聚氨酯树脂及其泡沫塑料

理化性质

甲苯二异氰酸酯为无色透明至淡黄色液体,有刺激性气味; 遇光颜色变深。分子式C9-H6-N2-O2。分子量174.16。相对密度1.22±0.01(25℃)。凝固点3.5～5.5 ℃(TDI-65); 11.5～13.5℃(TDI-80); 19.5～21.5℃。沸点251℃。闪点132℃(闭杯)。蒸气密度6.0。蒸气压0.13kPa(0.01mmHg20℃)。蒸气与空气混合物可燃限0.9～9.5% 。不溶于水; 溶于丙酮、乙酸乙酯和甲苯等。容易与包含有活泼氢原子的化合物:胺、水、醇、酸、碱发生反应,特别是与氢氧化钠和叔胺发生难以控制反应,并放出大量热。与水反应生成二氧化碳是聚氨酯泡沫塑料制造过程中的关键反应之一; 应避免受潮。在常温下聚合反应速度很慢,但加热至45℃以上或催化剂存在下能自聚生成二聚物。能与强氧化剂发生反应。遇热、明火、火花会着火。加热分解放出氰化物和氮氧化物。

消防措施

用干粉、二氧化碳灭火，大火用水施救。消防人员须穿戴防毒面具与防护服。

储运须知

包装标志：毒害品。包装方法：（II）类。铁桶装内充氮气。储运条件：储存于阴凉、干燥、通风良好的不燃材料结构的库房中，防止容器受损和受潮。储存温度控制在20-35℃。远离热源和火源、与胺类、醇、碱类和含水物品隔离储运。

泄漏处理

戴好防毒面具与手套。用四倍量消灰中和后扫起，倒至空旷地方掩埋或焚烧掉。对污染的地面用肥皂或洗涤剂刷洗，经稀释的污水放入废水系统。

接触机会

主要用于制造聚氨酯树脂及其泡沫塑料。生产和使用TDI者均可接触。

侵入途径

主要经呼吸道吸入,不能经无损皮肤吸收。

毒理学简介

大鼠经口LD50: 4130 mg/kg; 吸入LCLo: 600 ppm/6H。小鼠经口LD50: 1950 mg/kg; 吸入LC50: 9700 ppb/4H。兔经皮LD50: >10 mL/kg。

本品急性吸入毒性较高,经口毒性较低。主要有明显刺激和致敏作用。对眼、呼吸道粘膜和皮肤有刺激作用,并引起支气管哮喘。

人的嗅觉阈为0.35～0.92mg/m^3,另有报道为3mg/m^3。3～3.6mg/m^3时,对粘膜有刺激; 27.8mg/m^3时眼和呼吸道严重刺激。16mg/m^3,工作3～4周后,不少人出现急性上呼吸道炎; 0.5mg/m^3,工作一周,出现剧烈的咳嗽和呼吸困难。
TDI引起支气管哮喘,可能系异氰基团与体内的蛋白质的氨基结合后,生成异性蛋白,成为抗原诱发的变态反应; 也可同时有药理机制和刺激作用。

2,6-TDI的刺激作用比2,4-TDI为大。

临床表现

TDI主要影响呼吸系统。

接触较高浓度TDI时,可产生眼和上呼吸道刺激症状。眼部有发痒、辛辣痛感、流泪、视物模糊和结膜充血等症状,可发生角膜炎或角结膜炎; 并有咽喉干燥、剧烈咳嗽、胸闷、呼吸困难,可有喘息性支气管炎等症状。严重者可出现肺水肿。

部分工人经上述发作一次或数次之后,产生过敏。以后,即使极微量接触,亦能诱发支气管哮喘。哮喘发作前,有一定潜伏期。尤以夜间发作多见。一般脱离接触后可恢复,有时恢复较慢。

实验室检查如变应原皮肤试验、血清抗原特异性IgE测定、变应原支气管激发试验和肺功能测定等有助诊断。参见<职业性哮喘诊断标准及处理原则>。皮肤直接接触TDI,可产生刺激性接触性皮炎,也可引起变应性接触性皮炎。

处理

过量接触者应脱离现场。对症处理。哮喘性支气管炎和支气管哮喘发作时,可给予支气管解痉剂,如氨茶碱、喘定、异丙基肾上腺素等,并可给予抗过敏、祛痰、镇咳、抗炎等药物。严重者可应用糖皮质激素。接触性皮炎的治疗可参见
<化学物致刺激性接触性皮炎的治疗>。有明显的特应性体质者,如接触TDI后,反复发生过敏性哮喘或变应性接触性皮炎者应调离原工作。标准

车间空气卫生标准:
中国MAC 0.2mg/m^3;
美国ACGIH TLV-TWA 0.036mg/m^3, STEL 0.14mg/m^3
OEL-FRANCE: VME 0.01 ppm (0.08 mg/m3), VLE 0.02 ppm (0.16 mg/m3), JAN1999;
OEL-SWEDEN: TWA 0.005 ppm, CEILING 0.01 ppm, JAN1999;
OEL-UNITED KINGDOM: TWA 0.02 mg(NCO)/m3, STEL 0.07 mg(NCO)/m3, SEP2000

危规:2,4-甲苯二异氰酸酯 GB6.1 类61111。原铁规:有机有毒品,84052。UN NO.2078。IMDG CODE 6093-1页,6.1 类。

毒理学数据:

对人的眼睛黏膜和呼吸系统有强烈的刺激作用，与皮肤接触能引起发痒和脱皮。同时，也能破坏人体的蛋白质。生产设备应密闭，操作人员应穿戴劳保防护用具。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ9490000

CHEMICAL NAME :: Isocyanic acid, methyl-m-phenylene ester

CAS REGISTRY NUMBER :: 26471-62-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 41

MOLECULAR FORMULA :: C9-H6-N2-O2

MOLECULAR WEIGHT :: 174.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9700 ppb/4H

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11 ppm/4H

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 12700 ppb/4H

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15600 mg/kg/13W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ug/m3/24H/22W-C

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppb/6H/81D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 ppm/6H/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2830 ppb/6H/3W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 ppm/6H/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 46 ppb/1W-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 ppm/6H/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 29 ppb/8W-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31800 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63600 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,287,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,287,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TOLUENE DIISOCYANATE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3117 No. of Facilities: 2226 (estimated) No. of Industries: 32 No. of Occupations: 45 No. of Employees: 38881 (estimated) No. of Female Employees: 4723 (estimated)

危害码 (欧洲)	Xn
风险声明 (欧洲)	R26
安全声明 (欧洲)	23-36/37/39-45
危险品运输编码	UN 2078
RTECS号	NQ9490000
包装等级	II
危险类别	6.1(a)
海关编码	2929101000

1.由2,4-二氨基甲苯与光气作用制得。先将固体二氨基甲苯溶于氯化苯中，在搅拌下升温至70℃得二氨基甲苯氯苯溶液，将回收光气化的氧化苯，放入低温光气锅中，补加一定液体光气后，在搅拌下滴加配好的二氨基甲苯溶液，在40℃进行光气化，再将低温光气化的物料放入高温锅中进行高温光气化，边升温边通气，约4h，反应一般在120~125℃进行；反应完毕，经用氮气赶气、蒸馏、精馏而得。

海关编码	2929101000
中文概述	2929101000. 甲苯二异氰酸酯(TDI). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最低关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于日本、韩国、美国、欧盟的
Summary	2929101000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0%

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