2776-93-4

• 常用中文名：2-乙酰基-1-B-(L-天冬酰胺)-1,2-双脱氧-D-葡萄糖
• 常用英文名：N-Asn
• CAS号：2776-93-4
• 分子式：C₁₂H₂₁N₃O₈
• 分子量：335.31000
• 相关类别： 研究领域 其他
• 发布时间：2016-08-25 10:47:08
• 更新时间：2026-07-08 18:29:29
• H-Asn(glcnac-beta-D)-OH是尿中存在的内源性代谢产物,可用于NGLY1-CDDG[1][2]的研究。

名称

• 中文名: 2-乙酰基-1-B-(L-天冬酰胺)-1,2-双脱氧-D-葡萄糖
• 英文名: N4-(β-N-acetyl-D-glucosaminyl)-L-asparagine
• 中文别名: N4-((2R,3R,4R,5S,6R)-3-乙酰氨基-4,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)-L-天冬酰胺; 2-[2H3]乙酰氨基-2-脱氧-Β-D-吡喃葡萄糖基L-天冬酰胺; N-[2-(乙酰氨基)-2-脱氧-Β-D-吡喃葡萄糖基]-L-天冬酰胺; H-天冬酰胺(GLCNAC-Β-D)-OH; 2-乙酰氨基-2-脱氧-Β-D-吡喃葡萄糖基L-天冬酰胺
• 英文别名: 2-ACETAMIDO-1-N-(BETA-L-ASPTYL)-2-DEOXY-BETA-D-GLUCOPYRANOSYLAMINE; (2S)-4-[[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-2-azanyl-4-oxo-butanoic acid; 4-N-[B-GLCNAC]-L-ASN-OH; N-gamma-(2-Acetamido-2-deoxy-beta-D-gluco-pyranosy; 2-ACETAMIDO-1-N(B-L-ASPTYL)-2 DEOXYB-D -GLUCOPYRA; 2-Acetamido-2-deoxy-b-D-glucopyranosyl L-aspagine; 2-ACETAMIDO-1-BETA-[L-ASPTAMIDO]-1,2-DIDEOXY-D-GLUCOSE; L-ASPAGINE,N-[2-(ACETYLAMINO)-2-DEOXY-B-D-GLUCOPYRANOSYL]; Nγ-(2-Acetamido-2-deoxy-β-D-gluco-pyranosyl)-L-aspagine; 2-acetamido-2-deoxy-β-D-glucopyranosyl L-aspagine; (2S)-4-[[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-methylol-tetrahydropyran-2-yl]amino]-2-amino-4-keto-butyric acid; β-D-GlcNAc-(1→N)-Asn; N4-((2R,3R,4R,5S,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-L-aspagine; 2-Acetamido-1-β-(L-asptamido)-1,2-dideoxy-D-glucose; L-Aspagine, N-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]; L-Aspagine, N-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]; N-g-(2-AcetaMido-2-deoxy-b-D-gluco-pyranosyl)-L-aspagine; L-Asn(GlcNAc-β-D)-OH; H-Asn(GlcNAc-β-D)-OH; 2-Acetamido-1-N-(β-L-asptyl)-2-deoxy-β-D-glucopyranosylamine; n-acetylglucosaminylaspagine; (2-[2H3]acetamido-2-deoxy-β-D-glucopyranosyl L-aspagine); 2-acetamido-1-N(B-L-asptyl)-2 deoxy*B-D-glucopy; (2S)-4-[[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-2-amino-4-oxobutanoic acid; 2-Acetamido-1-N-(β-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine; N(4)-(beta-N-acetyl-D-glucosaminyl)-L-aspagine; H-Asn(GlcNAc-b-D)-OH; β-D-GlcNAc-(1-N)-Asn, 2-Acetamido-1-β-(L-asptamido)-1,2-dideoxy-D-glucose, 2-Acetamido-1-N-(β-L-asptyl)-2-deoxy-β-D-glucopyranosylamine; 4-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino-2-amino-4-oxo-butanoic acid; Asptylglycosamine; BETA-D-GLCNAC-1->N-ASN; β-d-glcnac-1→n-asn; 2-Acetamido-2-deoxy-b-D-glucopyranosyl L-asparagine; n-asn; H-Asn(β-D-glcnac)-OH; N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine

物化性质

• 密度: 1.53g/cm3
• 沸点: 818.5ºC at 760mmHg
• 分子式: C₁₂H₂₁N₃O₈
• 分子量: 335.31000
• 闪点: 448.8ºC
• 精确质量: 335.13300
• PSA: 191.44000
• 蒸汽压: 4.86E-31mmHg at 25°C
• 折射率: 1.6
• 储存条件: 2-8°C

生物活性

• 描述: H-Asn(glcnac-beta-D)-OH是尿中存在的内源性代谢产物,可用于NGLY1-CDDG[1][2]的研究。
• 相关类别:
  研究领域 >> 其他
• 体外研究: 内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。
• 参考文献:

  [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

  [2]. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372.

安全

• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

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