23443-25-6

• 常用中文名：6-甲氧基-1H-1,5-萘啶-4-酮
• 常用英文名：6-Methoxy-1,5-naphthyridin-4-ol
• CAS号：23443-25-6
• 分子式：C₉H₈N₂O₂
• 分子量：176.172
• 发布时间：2018-12-31 18:41:39
• 更新时间：2024-01-08 18:19:55

名称

• 中文名: 6-甲氧基-[1,5]-萘啶-4-醇
• 英文名: 6-methoxy-1H-1,5-naphthyridin-4-one
• 英文别名: 6-Methoxy-1,5-naphthyridin-4-ol; 6-methoxy-1,5-naphthyridine-4-ol; 6-methoxy-1H-[1,5]naphthyridin-4-one; 4-hydroxy-6-methoxy-[1,5]naphthyridine; 1,5-Naphthyridin-4-ol, 6-methoxy-; 6-(methyloxy)-1,5-naphthyridin-4-ol; 1,5-Naphthyridin-4-ol,6-methoxy

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 339.6±37.0 °C at 760 mmHg
• 分子式: C₉H₈N₂O₂
• 分子量: 176.172
• 闪点: 159.2±26.5 °C
• 精确质量: 176.058578
• PSA: 54.98000
• LogP: 1.78
• 外观性状: 固体
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.659
• 储存条件: 2-8°C， 密封， 干燥

安全

• 危害码 (欧洲): Xn
• 海关编码: 2933990090

合成路线

25063-69-8 ~86% 23443-25-6

文献：Gomez, Laurent; Hack, Michael D.; Wu, Jiejun; Wiener, John J.M.; Venkatesan, Hari; Santillan Jr., Alejandro; Pippel, Daniel J.; Mani, Neelakandha; Morrow, Brian J.; Motley, S. Timothy; Shaw, Karen Joy; Wolin, Ronald; Grice, Cheryl A.; Jones, Todd K. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2723 - 2727

405937-76-0 ~70% 23443-25-6

文献：SMITHKLINE BEECHAM P.L.C. Patent: WO2003/87098 A1, 2003 ; Location in patent: Page/Page column 37 ;

6628-77-9 922-67-8 ~68% 23443-25-6

文献：Davies, David Thomas; Markwell, Roger Edward; Pearson, Neil David Patent: US2004/53928 A1, 2004 ;

1242446-41-8 ~34% 23443-25-6

文献：SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; CASAUBON, Rebecca, L. Patent: WO2010/101949 A1, 2010 ; Location in patent: Page/Page column 125 ; WO 2010/101949 A1

577771-12-1 ~68% 23443-25-6

文献：GLAXO GROUP LIMITED Patent: WO2006/20561 A2, 2006 ; Location in patent: Page/Page column 29 ;

6628-77-9 2033-24-1 101-84-8 ~% 23443-25-6

文献：MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE Patent: WO2006/21448 A1, 2006 ; Location in patent: Page/Page column 28 ;

53241-85-3 ~% 23443-25-6

文献：SMITHKLINE BEECHAM PLC Patent: EP1214314 B1, 2005 ; Location in patent: Page/Page column 15 ;

6628-77-9 ~% 23443-25-6

文献：KYORIN PHARMACEUTICAL CO., LTD.; MERCK SHARP and DOHME CORP.; FUKUDA, Yasumichi; KAELIN, David E. Jr.; SINGH, Sheo B. Patent: WO2013/3383 A1, 2013 ;

上下游产品

上游产品  8
25063-69-8 405937-76-0 6628-77-9 922-67-8
1242446-41-8 577771-12-1 2033-24-1 101-84-8
下游产品  3
724788-70-9 249889-68-7 881658-92-0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%