| 英文名 | (2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid |
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| 描述 | MK-0533 是一种新型 PPARγ 部分激动剂,可用于预防血管内皮功能障碍(VED)和VED相关心血管疾病。 |
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| 参考文献 | 1. Acton JJ 3rd, et al. Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume. J Med Chem. 2009 Jul 9;52(13):3846-54. |
| 分子式 | C28H24F3NO6 |
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| 分子量 | 527.48800 |
| 精确质量 | 527.15600 |
| PSA | 86.99000 |
| LogP | 6.31910 |