668455-28-5

668455-28-5 structure

Name: (2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid
Chemical Name: (2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid
CAS Number: 668455-28-5
Molecular Formula: C₂₈H₂₄F₃NO₆
Molecular Weight: 527.48800
Create Date: 2016-07-06 14:46:50
Modify Date: 2022-09-16 18:03:46
MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.

Name	(2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid

Description	MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.
References	1. Acton JJ 3rd, et al. Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume. J Med Chem. 2009 Jul 9;52(13):3846-54.