101666-68-6

• 常用中文名：N-去甲基克拉霉素
• 常用英文名：N-Demethylclarithromycin
• CAS号：101666-68-6
• 分子式：C₃₇H₆₇NO₁₃
• 分子量：733.92700
• 发布时间：2019-01-14 19:33:50
• 更新时间：2026-07-17 22:44:56

名称

• 中文名: N-去甲基克拉霉素
• 英文名: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-6-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
• 中文别名: 克拉霉素杂质04; 克拉霉素杂质D(N-去甲基克拉霉素); 克林霉素杂质D; 克拉霉素杂质D(N-地甲基克拉霉素); 克拉霉素杂质D; N-脱甲基克拉霉素; N-去甲克拉霉素; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-乙基-12,13-二羟基-4-(((2R,4R,5S,6S)-5-羟基- 4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基)氧基)-6-(((2S,3R,4S,6R)-3-羟基-6-甲基-4-(甲基氨基)四氢- 2H-吡喃-2-基)氧基)-7-甲氧基-3,5,7,9,11,13-六甲基氧杂环十四烷-2,10-二酮 (克拉霉素杂质); 克拉霉素杂质D 标准品; 甲基红霉素 杂质D; 克拉红霉素 杂质D; 克拉霉素杂质1(克拉霉素杂质D); 克拉霉素杂质D(N-甲基克拉霉素)
• 英文别名: N-Demethyl-6-O-methylerythromycin; Clithromycin Impurity D (N-Desmethyl Clithromycin/ N-Demethyl-6-O-methylerythromycin A); Clithromycin Impurity D (N-desmethyl clithromycin); (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione; N-Desmethyl Clithromycin; 4'-desmethylclarithromycin; N-DeMethyl-6-O-MethylerythroMycin; N-des-methylclarithromycin; de(N-methyl)-6-O-methyl erythromycin; Clithromycin Impurity 1(Clithromycin Impurity D); (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrah; Clithromycin Impurity D (10 mg) (N-desmethyl clithromycin); 3″-N-Demethyl-6-O-methylerythromycin A; (3R,4S,5S,6R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3; Clithromycin Impurity 4; Claricid Impurity 1; de(N-methyl) erythromycin A; Erythromycin, N-demethyl-6-O-methyl; Clithromycin Impurity D/N-Desmethyl Clithromycin/(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrah; 3"-N-DeMethylclithroMycin; 3&3'-N-demethyl-6-O-methylerythromycin A; Clithromycin Impurity D; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (Clithromycin Impurity)

物化性质

• 密度: 1.18±0.1 g/cm3 (20 ºC 760 Torr)
• 熔点: 231-233 ºC
• 分子式: C₃₇H₆₇NO₁₃
• 分子量: 733.92700
• 精确质量: 733.46100
• PSA: 191.70000
• LogP: 2.48840

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

81103-11-9 ~92% 101666-68-6

文献：RIB-X-PHARMACEUTICALS, INC. Patent: WO2008/106204 A1, 2008 ; Location in patent: Page/Page column 112 ;

81103-11-9 ~% 118058-75-6 101666-68-6

文献：US2009/76253 A1, ; Page/Page column 40 ;

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