31618-90-3

• 常用中文名：对甲苯磺酰氧甲基膦酸二乙酯
• 常用英文名：Diethyl tosyloxy methylphosphonate
• CAS号：31618-90-3
• 分子式：C₁₂H₁₉O₆PS
• 分子量：322.314
• 相关类别： 有机原料 有机膦化合物
• 发布时间：2018-02-03 08:00:00
• 更新时间：2026-07-04 21:55:09

名称

• 中文名: 对甲苯磺酰氧甲基膦酸二乙酯
• 英文名: diethoxyphosphorylmethyl 4-methylbenzenesulfonate
• 中文别名: 对甲苯磺酰氧甲基膦酸二乙酯(富马酸泰诺福韦酯中间体); 对甲苯磺酰氧基甲基膦酸二乙酯 替诺福韦中间体; 阿德福韦杂质6 CRS; DESMP对甲苯磺酰氧甲基膦酸二乙酯; 对甲苯磺酰氧甲基瞵酸二乙酯; 对甲苯磺酰氧甲基膦酸; 对甲苯磺酰氧甲基膦酸二乙酯(DESMP); (对甲苯磺酰氧代甲基)膦酸二乙酯; 对甲苯磺酰氧甲基磷酸二乙酯; 替诺福韦中间体; 替诺福韦酯杂质36; 对甲苯磺酰氧甲基瞵酸二乙酯(DESMP); (二乙氧基磷酰基)甲基4-甲基苯磺酸酯; 对甲苯磺酰氧基甲基膦酸二乙酯(31-3); 对甲苯磺酰氧甲基磷酸二乙酯(DTP); 对甲本磺酰基磷酸二乙酯; 替诺福韦杂质66; 对甲苯磺酰氧甲基磷酸二乙酯DESMP; (甲苯磺酰氧基)甲基膦酸二乙酯; (二乙氧基磷酰基)甲基4-甲基苯磺酸; 发货31618-,泰诺福韦中间体31-3; 二乙基(托昔洛克)膦酸甲酯; 泰诺福韦杂质36; 对甲苯磺酰氧甲基膦酸二乙酯(富马酸替诺福韦中间体); 替诺福韦酯杂质86; 对甲苯磺酰氧甲基麟酸二乙酯; 甲苯磺酰氧甲基膦酸二乙酯; 4-甲苯磺酰氧甲基磷酸二乙酯; 对甲苯磺酰氧基甲基膦酸二乙酯; (二乙氧基磷酰基)甲基4-甲基苯磺酸盐; 对甲苯磺酰甲氧基磷酸二乙酯
• 英文别名: Diethyl P-tolunesulponyloxyMethyl Phosphonate; Phosphonic acid,P-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, diethyl ester; Tenofovir disoproxil Impurity 86; diethyl [[[(4-tolyl)sulfonyl]oxy]methyl]phosphonate; tosyloxymethyl diethyl phosphonate; Diethyl (tosyloxy)methylphosphonate Diethyl; Diethyl p-toluenesulfonyloxy Methylphosphonate (DMESP/TSD/DESMP); 4-METHYLPHENYL]SULFONYL]OXY]METHYLPHOSPHONICACIDDIETHYLESTER; TOLUENE-4-SULFONIC ACID DIETHOXY-PHOSPHORYLMETHYL ESTER; DIETHYL P TOLUENE SULPHONYLOXY METHYL PHOSPHONATE; P-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]phosphonic Acid Diethyl Ester; (Diethoxy-phosphoryl)methyl tosylate; DIETHYL 4-TOLUENESULFONYLOXYMETHYLPHOSPHONATE; [[[(4-Tolyl)sulfonyl]oxy]methyl]phosphonic acid diethyl ester; p-Toluenesulfonic Acid (Diethoxyphosphoryl)methyl Ester; (DIETHOXYPHOSPHORYL)METHYL 4-METHYLBENZENESULFONATE; Diethyl(p-Toluenesulfonyloxymethyl)phosphonate>; Diethyl(Tosyloxy)methylphosphonte; Diethyl p-tosyloxymethylphosphonate; Adefovir Impurity 6 CRS; Diethyl p-toluenesulfonyloxymethylpate; (Diethoxyphosphoryl)methyl 4-methylbenzenesulfote; Tenofovir intermediate; Diethyl (tosyloxy)methylphosphonate/DESMP; DETHYL (TOSYLOXY) METHYLPHOSPHONATE; [[[(4-Tolyl)sulfonyl]oxy]methyl]phosphonic acid di; (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate; Diethyl(tosyloxy)methylphosphonate; Adefovir Impurity 6; oxy)methyL; 1,3-dimethyl-36-nitrosourea; DESMP; (Diethoxyphosphoryl)methyl p-Toluenesulfonate; DESMP (DMESP/TSD; Diethyl (patoluenesulfonylmethyl)phosphonate; Diethyl-p-toluensulfonyloxyMethyl phosphonate(DESMP); Tenofovir Impurity 36; DIETHYL P-TOLUENESULFONYLOXYMETHYLPHOSPHONATE; Diethyl P-Toluenesulfonyl OxyMethyl Phosphonate (DESMP); DIETHYL(TOSYLOXYMETHYL)PHOSPHONATE; Diethyl (tosyloxy)methylphosphonate; Diethoxyphosphoryl methyl 4- methylbe; iethoxyphosphorylmethyl4-methylbenzenesulfonate; diethyl p-toluenesulfonyloxymethylphosphonate; MFCD03412078; Diethyl P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]phosphonate; DETHYL(TOSYLOXY)METHYLPHOSPHONATE; Diethyl [[[(4-tolyl)sulfonyl]oxy]Methyl]phosphonate(DESMP); Diethyl (p-Toluenesulfonyloxymethyl)phosphonate; Diethyl (tosyloxy)methylphosphonateQ: What is Diethyl (tosyloxy)methylphosphonate Q: What is the CAS Number of Diethyl (tosyloxy)methylphosphonate Q: What is the storage condition of Diethyl (tosyloxy)methylphosphonate Q: What e the applications of Diethyl (tosyloxy)methylphosphonate; diethyl 4-methylbenzenesulfonyloxymethylphosphonate; Diethylp-toluenesulfonyloxymenthylphosphonate; PHOSPHONIC ACID, [[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, DIETHYL ESTER (9CI); p-toluenesulfonyloxy methylphosphonate; (p-Toluenesulfonyloxymethyl)phosphonic Acid Diethyl Ester; Diethyl p-tolene sulfonyloxy methyl phosphonate; Ethy16,8-dichlorooctanoate; Phosphonic acid, P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester; Diethyl p-tolunesulponyloxymethyl phosphonate; Diethyl patoluenesulfonylmethyl phosphonate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 441.7±28.0 °C at 760 mmHg
• 分子式: C₁₂H₁₉O₆PS
• 分子量: 322.314
• 闪点: 220.9±24.0 °C
• 精确质量: 322.063995
• PSA: 97.09000
• LogP: 1.51
• 外观性状: 淡黄色油状
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.498
• 储存条件: Refrigerator, Under Inert Atmosphere

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Diethyl (tosyloxy)methylphosphonate Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Diethyl (tosyloxy)methylphosphonate CAS number:31618-90-3 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C12H19O6PS Molecular weight:322.3 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2930909090

合成路线

50-00-0 762-04-9 98-59-9 ~79% 31618-90-3

文献：Kopcho, Joseph J.; Reddy, K. Raja; Matelich, Michael C.; Ugarkar, Bheemarao G. Patent: US2003/225277 A1, 2003 ; Location in patent: Page 10 ;

3084-40-0 ~75% 31618-90-3

文献：CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE LA MEDITERRANEE; K.U. LEUVEN RESEARCH and DEVELOPMENT Patent: WO2008/56264 A2, 2008 ; Location in patent: Page/Page column 71-72 ;

3084-40-0 98-59-9 ~98% 31618-90-3

文献：Merlo, Valeria; Roberts, Stanley M.; Storer, Richard; Bethell, Richard C. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 11 p. 1477 - 1482

762-04-9 98-59-9 ~% 31618-90-3

文献：EP1243590 A2, ; Page 9 ;

7016-78-6 ~% 31618-90-3

文献：Collection of Czechoslovak Chemical Communications, , vol. 47, # 12 p. 3447 - 3463

上下游产品

上游产品  4
50-00-0 762-04-9 98-59-9 3084-40-0
下游产品  10
143056-54-6 38066-16-9 180587-75-1 683-08-9
10419-77-9 106941-25-7 147127-20-6 116384-53-3
1068-07-1 120362-30-3

海关

海关编码	2931900090
中文概述	2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%