106006-84-2

• 常用中文名：s-2-氨基-6-丙酰氨基-4,5,6,7-四氢苯并噻唑
• 常用英文名：(6S)-2-Amino-6-propionamidotetrahydrobenzothiazole
• CAS号：106006-84-2
• 分子式：C₁₀H₁₅N₃OS
• 分子量：225.311
• 发布时间：2018-08-10 20:19:30
• 更新时间：2026-07-29 14:06:33
• 【用途一】
  用于制备抗帕金森氏病用药普拉克索

名称

• 中文名: s-2-氨基-6-丙酰氨基-4,5,6,7-四氢苯并噻唑
• 英文名: (-)-2-Amino-6-propionamido-tetrahydrobenzothiazole
• 中文别名: 普拉克索杂质E /BP); (S)-N-(2-氨基-4,5,6,7-四氢苯并[D]噻唑-6-基)丙酰胺; S-2-氨基-6-丙酰氨基-4,5,6,7-四氢苯并噻唑; (-)-2-氨基-6-丙酰胺四氢苯并噻唑/(S) - 普拉克索酰胺; 盐酸普拉克索杂质5(盐酸普拉克索杂质E); (-)-2-氨基-6-丙酰胺基-4,5,6,7-四氢苯并噻唑; 盐酸普拉克索杂质D-1对照品; 普拉克素杂质HB1755CL; 盐酸普拉克索杂质E; 普拉克索杂质; 普拉克索杂质E; 化合物 (S)-N-(2-AMINO-4,5,6,7-TETRAHYDROBENZO[D]THIAZOL-6-YL)PROPIONAMIDE; (6S)-2-氨基-6-丙酰氨基四氢苯并噻唑; S-(-)-2-氨基-6-丙酰胺基-4,5,6,7-四氢苯并噻唑
• 英文别名: N-[(6S)-2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]propanamide; Prakasol impurity E; (-)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzothiazole; N-(2-amino-2,3,3a,7a-tetrahydrobenzo[d]thiazol-6-yl)propionamide; (6S)-N6-Propionyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine; ()-2-Amino-6-propionamido-tetrahydrobenzothiazole; Pramipexole Impurity E/ Pramipexole Related Compound B ((S)-Pramipexole Amide); (S)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPION; Pramipexole Dihydrochloride Monohydrate Impurity E; Pramipexole impurity 5/Pramipexole Impurity E/Pramipexole propionamide; pramipexole impurities1164; s-2-amino-6-propionamide-4,5,6,7-tetrahydrobenzothiazole; (S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole; Pramipexole Impurity V; (S)-2-Amino-6-propionylamino-4,5,6,7-tetrahydrobenzothiazole; Pramipexole Impurity 5(Pramipexole Impurity E); (S)-N-(2-AMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-6-YL)-PROPIONAMIDE; (S)-Pramipexole amide, Pramipexole related compound B,N-[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]propanamide; Pramipexole-3; MFCD07369803; PraMipexole IMpurity E; (-)-2-Amino-6-propionamido-tetrahydro-benzothiazole; (S)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide; (6S)-2-AMINO-6-PROPIONAMIDOTETRAHYDROBENZOTHIAZOLE; (S)-2-Amino-4,5,6,7-tetrahydro-6-(1-oxo-propylamino)benzothiazole; Pramipexole Impurity V/(S)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide; N-[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]propanaMide; N-[(6S)-2-amino-4,5,6,7-tetrahydro-6-benzothiazolyl]-Propanamide; 2-amino-6-acetylamino-4,5,6,7-tetrahydrobenzothiazole; (S)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionaMide; (S)-2-AMINO-6-PROPIONAMIDOTETRAHYDROBENZOTHIAZOLE; PropanaMide, N-[(6S)-2-amino -4,5,6,7-tetrahydro-6- benzothiazolyl]; Praxsol Hydrochloride Impurity E; (S)-2-AMINO-6-PROPIONAMIDO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE; N-((6S)-2-amino-3a,4,5,6,7,7a-hexahydrobenzo[d]thiazol-6-yl)propionamide; T56 BN DS&TJ CZ GMV2 &&S Form

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 502.9±39.0 °C at 760 mmHg
• 熔点: 187-188ºC
• 分子式: C₁₀H₁₅N₃OS
• 分子量: 225.311
• 闪点: 257.9±27.1 °C
• 精确质量: 225.093582
• PSA: 96.25000
• LogP: 0.90
• 外观性状: 灰白色固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.596
• 储存条件: Refrigerator

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

合成路线

123-62-6 106092-09-5 ~89% 106006-84-2

文献：Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498

106006-83-1 ~% 106006-84-2

文献：Journal of Medicinal Chemistry, , vol. 30, # 3 p. 494 - 498

104617-50-7 ~% 106006-84-2

文献：WO2011/21214 A2, ;

27514-08-5 ~% 106006-84-2

文献：WO2011/21214 A2, ;

375824-96-7 ~% 106006-85-3 106006-84-2

文献：WO2006/12276 A1, ; Page/Page column 17-18 ;

上下游产品

上游产品  6
123-62-6 106092-09-5 106006-83-1 104617-50-7
27514-08-5 375824-96-7
下游产品  2
104632-25-9 104632-26-0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%