880468-89-3

• 常用中文名：(R)-2-Boc-3-甲氧基丙苄酰胺
• 常用英文名：(R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate
• CAS号：880468-89-3
• 分子式：C₁₆H₂₄N₂O₄
• 分子量：308.373
• 发布时间：2018-11-24 20:33:39
• 更新时间：2026-07-14 18:42:47

名称

• 中文名: 拉科酰胺中间体
• 英文名: (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate
• 中文别名: (R)-叔丁基 1-(苄基氨基)-3-甲氧基-1-氧代丙烷-2-氨基甲酸酯; 拉考沙胺中间体-酰胺; 拉考沙胺杂质M; 拉科酰胺杂质A; (R)-2-叔丁氧羰基氨基-N-苄基-3-甲氧基丙酰胺; (R)-1-(苄基氨基)-3-甲氧基-1-氧代丙烷-2-氨基甲酸叔丁酯; (R)-叔丁基1-(苄氨基)-3-甲氧基-1-氧丙烷-2-基氨基甲酸酯; 拉科酰胺杂质17对照品; (R)-2-BOC-3-甲氧基丙苄酰胺; 拉克酰胺中间体1; (R)-2-BOC-3-甲氧基丙苄酰胺 拉克酰胺中间体1; 1 - 氯-4 -(2 - 硝基乙烯基)苯; (R)-2-叔丁氧羰基氢基-N-苄基-3-甲氧基丙酰胺; 拉科酰胺杂质30; (R)-2-叔丁氧羰基氨基-N-苄基-3-甲氧基丙酰胺(N-2)
• 英文别名: LACOSAMIDE IMPURITY A/ (R)-TERT-BUTYL (1- (BENZYLAMINO)-3-METHOXY-1-OXOPROPAN-2- YL)CBAMATE; tert-butyl N-[(1R)-1-(benzylcbaMoyl)-2-Methoxyethyl]cbaMate; tert -Butyl [(2R)-1 -(benzylamino)-3-methoxy-1 -oxopropan-2-yl]cbamate; (R)-TERT-BUTYL-1-(BENZYLAMINO)-3-METHOXY-1-OXOPROPAN-2-YLCARBAMATE; tert-Butyl N-[(1R)-1-(methoxymethyl)-2-oxo-2-[(benzyl)amino]-ethyl]cbamate; Carbamic acid, N-[(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester; (R)-2-tert-butoxycbonylamino-N-benzyl-3-methoxypropionamide; Cbamic acid,[(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethylester (9CI); 2-Methyl-2-propanyl [(2R)-1-(benzylamino)-3-methoxy-1-oxo-2-propanyl]carbamate; tert-Butyl 1-(benzylamino); (R)-tertbuftyl-1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcbamate; 3-methoxy-1-oxopropan-2-ylcbamate; Lacoamide Impurity 18; N-[3-methoxy-1-oxo-1-[(phenylmethyl)amino]propan-2-yl]cbamic acid tert-butyl ester; (R)-N-benzyl-2-N-Boc-amino-3-methoxypropionamide; O-methyl-N-alpha-[phenylmethoxy]carbonyl]-N-(phenylmethyl)-D-Serinamide; LacosaMide interMediate; Lacosamide impurity A CRS; (R)-2-tert-butyryl amino-benzylyl-3-methoxypropamide; Cbamic acid, N-[(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester; Tert-butyl of (R) 1- (butylamino) -3-methoxy-1-oxypropane-2-yl cbamate; (R)-tert-Butyl1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcbamate; (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxoprop; TERT-BUTYL N-[(1R)-1-(BENZYLCARBAMOYL)-2-METHOXYETHYL]CARBAMATE; 1,1-Dimethylethyl N-[(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]cbamate; (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcbamate; tert-butyl N-[(1R)-2-(benzylamino)-1-(methoxymethyl)-2-oxo-ethyl]cbamate; (R)-tert-Butyl 1-(benzylamino)-3-methoxy-1-oxopropan-2-ylc; tert-butyl (R)-(1-(benzylamino)-3-methoxy-1-oxopropan-2-yl)cbamate

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 507.6±50.0 °C at 760 mmHg
• 熔点: 63-64°C
• 分子式: C₁₆H₂₄N₂O₄
• 分子量: 308.373
• 闪点: 260.8±30.1 °C
• 精确质量: 308.173615
• PSA: 76.66000
• LogP: 2.55
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.510
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 海关编码: 2924299090

合成路线

3850-40-6 ~% 880468-89-3

文献：MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SRINIVAS, Aluru; SATYANARAYANA, Revu Patent:   WO2011/99033 A1, 2011 ;

3850-40-6 100-46-9 ~% 880468-89-3

文献：Archimica GmbH Patent:   EP2399901 A1, 2011 ;

1253790-58-7 77-78-1 ~77% 880468-89-3

文献：WISDOM, Richard; JUNG, Joerg; MEUDT, Andreas Patent: US2011/319649 A1, 2011 ; Location in patent: Page/Page column 5 ;

100-46-9 86123-95-7 ~90% 880468-89-3

文献：COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH; MURUGAN, Muthukrishnan; MUJAHID, Mohammad; MUJUMDAR, Prashant Pramod Patent: US2014/12044 A1, 2014 ; Location in patent: Paragraph 0074; 0075 ;

3262-72-4 ~% 880468-89-3

文献：WO2011/99033 A1, ;

24424-99-5 ~% 880468-89-3

文献：WO2011/99033 A1, ;

3262-72-4 100-46-9 ~% 880468-89-3

文献：EP2399901 A1, ;

100-46-9 ~% 880468-89-3

文献：WO2011/144983 A2, ;

上下游产品

上游产品  7
1253790-58-7 77-78-1 100-46-9 86123-95-7
3262-72-4 24424-99-5 3850-40-6
下游产品  1
196601-69-1

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%