32854-75-4

• 常用中文名：高乌甲素
• 常用英文名：Lappaconitine
• CAS号：32854-75-4
• 分子式：C₃₂H₄₄N₂O₈
• 分子量：584.700
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-05-30 08:00:00
• 更新时间：2024-01-02 17:23:32
• 高乌甲素 (Lappaconitine) 是从高乌头中分离到的一种天然产物,具有镇痛作用。

名称

• 中文名: 高乌甲素
• 英文名: Lannaconitine
• 中文别名: 刺乌头碱; 乌头提取物
• 英文别名: LAPPACONITINE; (1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol 4-[2-(Acetylamino)benzoate]; acetyl-10-deoxysepaconitine; (1α,14α,16β)-20-Ethyl-8,9-dihydroxy-1,14,16-trimethoxyaconitan-4-yl 2-acetamidobenzoate; Benzoic acid, 2-(acetylamino)-, (1α,14α,16β)-20-ethyl-8,9-dihydroxy-1,14,16-trimethoxyaconitan-4-yl ester; N-Acetylpuberanidine; lappaconintine; Aconitum kusnezoffii Reichb

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 720.7±60.0 °C at 760 mmHg
• 熔点: 217-218ºC
• 分子式: C₃₂H₄₄N₂O₈
• 分子量: 584.700
• 闪点: 389.7±32.9 °C
• 精确质量: 584.309753
• PSA: 126.79000
• LogP: 2.13
• 外观性状: 白色粉末
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.624
• 储存条件: 2-8C

生物活性

• 描述: 高乌甲素 (Lappaconitine) 是从高乌头中分离到的一种天然产物,具有镇痛作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> P2X受体
  天然产物 >> 生物碱
  研究领域 >> 其他
• 参考文献:

  [1]. Guo X, et al.Effects of central Ca2+ on analgesic action of lappaconitine. Zhongguo Yao Li Xue Bao. 1989 Nov;10(6):504-7.

  [2]. Ono M, et al. Pharmacological studies of lappaconitine: supraspinal-spinal interaction in antinociception. Archives Internationales de Pharmacodynamie et de Therapie [1991, 309:32-41]

  [3]. Heubach JF, et al. Cardiac effects of lappaconitine and N-deacetyllappaconitine, two diterpenoid alkaloids from plants of the Aconitum and Delphinium species. Planta Med. 1998 Feb;64(1):22-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AR5569552 CHEMICAL NAME : Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)- CAS REGISTRY NUMBER : 32854-75-4 BEILSTEIN REFERENCE NO. : 0072755 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C32-H44-N2-O8 MOLECULAR WEIGHT : 584.78 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,301,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 7,337,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,301,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 7,337,1951

合成路线

433717-26-1 74-96-4 ~67% 32854-75-4

文献：Pankrushina; Nikitina; Anferova; Osadchii; Shakirov; Shults; Tolstikov Russian Chemical Bulletin, 2003 , vol. 52, # 11 p. 2490 - 2499

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