上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：苯丙氨酯
纯度：97.0%
规格：
联系人：徐经理
联系电话：13311869306

上海吉至生化科技有限公司
上海市上海市奉贤区
产品名：苯丙氨酯
纯度：97.0%
规格：250mg/10g/1g/5g
联系人：刘佳
联系电话：18116092098

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：苯丙氨酯
纯度：97.0%
规格：1g/5g/100g/25g
联系人：阿拉丁
联系电话：400-620-6333

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]苯丙氨酯,≥97%
纯度：97.0%
规格：100g/25g/1g/5g
联系人：夏言
联系电话：18016376636

西安康诺化工有限公司
陕西省西安市雁塔区
产品名：苯丙氨酯
纯度：98.5%
规格：1kg
联系人：高经理
联系电话：13289246953

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673-31-4生产厂家

673-31-4价格

673-31-4

673-31-4结构式

常用中文名：苯丙氨酯
常用英文名：phenprobamate
CAS号：673-31-4
分子式：C₁₀H₁₃NO₂
分子量：179.216
相关类别：原料药 Anesthetic Agents 骨骼肌松弛药
发布时间：2018-06-20 21:37:28
更新时间：2024-01-01 21:05:00
苯丙氨酯(3-苯基丙基氨基甲酸酯；MH 532；普罗福米芬)是一种广泛使用的中枢作用骨骼肌松弛剂,具有镇静和抗惊厥作用[1]。

化源商城直购

中文名	苯丙氨酯
英文名	3-phenylpropyl carbamate
中文别名	3-苯基-1-丙醇氨基甲酸酯苯丙氨酸
英文别名	Quamaquil Extacol Proformiphen Carbamic Acid 3-Phenylpropyl Ester phenprobamate Nelaxan 3-Phenylpropyl carbamate Gamaquil EINECS 211-606-1 MFCD00868163 Methanol, 1-imino-1-(3-phenylpropoxy)- Eirenal benzenepropanol g-Phenylpropyl Carbamate 3-Phenylpropyl hydrogen carbonimidate Palmita Ansepron Benzenepropanol, carbamate Actiphan Actozine

描述	苯丙氨酯(3-苯基丙基氨基甲酸酯；MH 532；普罗福米芬)是一种广泛使用的中枢作用骨骼肌松弛剂,具有镇静和抗惊厥作用[1]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 神经疾病
参考文献	[1]. J X Sun, et al. High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharm Drug Dispos. Jul-Aug 1987;8(4):341-51.

密度	1.1±0.1 g/cm3
沸点	295.5±33.0 °C at 760 mmHg
熔点	101-104℃
分子式	C₁₀H₁₃NO₂
分子量	179.216
闪点	132.5±25.4 °C
精确质量	179.094635
PSA	52.32000
LogP	2.16
蒸汽压	0.0±0.7 mmHg at 25°C
折射率	1.519
储存条件	室温
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:5 5.互变异构体数量:2 6.拓扑分子极性表面积:52.3 7.重原子数量:13 8.表面电荷:0 9.复杂度:153 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB9275000

CHEMICAL NAME :: 1-Propanol, 3-phenyl-, carbamate

CAS REGISTRY NUMBER :: 673-31-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-N-O2

MOLECULAR WEIGHT :: 179.24

WISWESSER LINE NOTATION :: ZVO3R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1110 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,856,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,140,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1047,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

海关编码	2924299090

122-97-4

622-46-8

~96%

673-31-4

文献：Ichikawa, Yoshiyasu; Morishita, Yukinori; Kusaba, Shuhei; Sakiyama, Naoto; Matsuda, Yasunori; Nakano, Keiji; Kotsuki, Hiyoshizo Synlett, 2010 , # 12 p. 1815 - 1818

122-97-4

673-31-4

文献：European Journal of Organic Chemistry, , # 5 p. 908 - 911

122-97-4

143-33-9

673-31-4

文献：Chemical and Pharmaceutical Bulletin, , vol. 33, # 6 p. 2403 - 2410

上游产品 3
122-97-4 622-46-8 143-33-9
下游产品 0

【方法一】
由3-苯丙醇与氰酸钠缩合、水解而得。将无水甲苯、3-苯丙醇及氰酸钠加入反应罐中，冷至10℃，搅拌下导入氯化氢气体，约80min，温度上升至55℃后开始下降。通气毕，在55-60℃反应0.5h。冷至30℃，加入氨水升温至70℃，静置0.5h，分取有机层，过滤，滤液冷却结晶。过滤，结晶用甲苯洗涤，再用蒸馏水洗至氯根符合要求止。气流干燥，得苯丙氨酯。

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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