CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XT1300000
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CHEMICAL NAME :
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Toluene, dinitro-
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CAS REGISTRY NUMBER :
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25321-14-6
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LAST UPDATED :
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199803
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DATA ITEMS CITED :
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34
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MOLECULAR FORMULA :
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C7-H6-N2-O4
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MOLECULAR WEIGHT :
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182.15
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WISWESSER LINE NOTATION :
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WNR X1 XNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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750 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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1300 mg/kg
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4550 ug/kg/26W-I
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TOXIC EFFECTS :
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Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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12775 mg/kg/Y-C
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1050 mg/kg
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SEX/DURATION :
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female 7-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - delayed effects
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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196 mg/kg
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SEX/DURATION :
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female 7-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - behavioral
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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2100 mg/kg
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SEX/DURATION :
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female 7-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1400 mg/kg
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SEX/DURATION :
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female 7-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
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TYPE OF TEST :
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Morphological transformation
MUTATION DATA
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TEST SYSTEM :
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Rodent - rat
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 14,155,1989 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,93,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 1.5 mg/m3;Skin JAN 1993 OEL-AUSTRALIA:TWA 1.5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 1.5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 1.5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-INDIA:TWA 1.5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 1.5 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 1.5 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 1.5 mg/m3;Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 1.5 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 1.5 mg/m3;STEL 5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DINITROTOLUENE-air:10H CA TWA 1.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
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