4299-03-0

• 常用中文名：Nα-苯甲酰基-L-精氨酰胺盐酸盐单水合物
• 常用英文名：Bz-Arg-NH2 HCl
• CAS号：4299-03-0
• 分子式：C₁₃H₁₉N₅O₂
• 分子量：277.322
• 相关类别： 生物化工 氨基酸及其衍生物 其他保护氨基酸
• 发布时间：2018-11-24 07:34:36
• 更新时间：2024-01-11 19:37:46
• (S) -N-(1-氨基-5-胍基-1-氧opentan-2-基)苯甲酰胺盐酸盐是精氨酸衍生物[1]。

名称

• 中文名: N-ALPHA-苄基-L-精氨酰胺盐酸盐
• 英文名: (S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride
• 中文别名: 苯甲酰-L-精氨酸乙酯盐酸盐; 苄基-L-精氨酰胺二盐酸盐; Nα-苯甲酰基-L-精氨酰胺盐酸盐单水合物
• 英文别名: Benzamide, N-[1-(aminocarbonyl)-4-[(diaminomethylene)amino]butyl]-; EINECS 224-307-6; N-ALPHA-BENZOYL-L-ARGININAMIDE HYDROCHLORIDE; N-α-BENZOYL-L-ARGININAMIDE HYDROCHLORIDE; N-benzoylargininamide; MFCD00035003; Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate; benzamide, N-[1-(aminocarbonyl)-4-[(aminoiminomethyl)amino]butyl]-; N-{1-Amino-5-[(diaminomethylene)amino]-1-oxo-2-pentanyl}benzamide; Bz-Arg-NH2 HCl

物化性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₃H₁₉N₅O₂
• 分子量: 277.322
• 精确质量: 277.153870
• PSA: 134.09000
• LogP: -0.12
• 外观性状: 固体;White to Light yellow powder to crystal
• 折射率: 1.625
• 储存条件:

  避光，通风干燥处，密封保存

• 稳定性:

  常温常压下稳定

• 分子结构:

  1、 摩尔折射率：73.46

  2、 摩尔体积（m³/mol）：207.7

  3、 等张比容（90.2K）：573.8

  4、 表面张力（dyne/cm）：58.2

  5、 极化率（10 ^-24cm ³）：29.12

• 计算化学:

  1、 氢键供体数量：5

  2、 氢键受体数量：5

  3、 可旋转化学键数量：7

  4、 互变异构体数量：8

  5、 拓扑分子极性表面积（TPSA）：137

  6、 重原子数量：21

  7、 表面电荷：0

  8、 复杂度：360

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：1

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：2

• 更多:

  1. 性状：不确定

  2. 密度（g/mL, 25℃）：不确定

  3. 相对蒸汽密度（g/mL,空气=1）：不确定

  4. 熔点（ºC）：不确定

  5. 沸点（ºC,常压）：不确定

  6. 沸点（ºC, 93pa）：不确定

  7. 折射率：不确定

  8. 闪点（ºF）：不确定

  9. 比旋光度（º, C=4, H2O）：6.5

  10. 自燃点或引燃温度（ºC）：不确定

  11. 蒸气压（kPa,25ºC）：不确定

  12. 饱和蒸气压（kPa,60ºC）：不确定

  13. 燃烧热（KJ/mol）：不确定

  14. 临界温度（ºC）：不确定

  15. 临界压力（KPa）：不确定

  16. 油水（辛醇/水）分配系数的对数值：不确定

  17. 爆炸上限（%,V/V）：不确定

  18. 爆炸下限（%,V/V）：不确定

  19. 溶解性：不确定

生物活性

• 描述: (S) -N-(1-氨基-5-胍基-1-氧opentan-2-基)苯甲酰胺盐酸盐是精氨酸衍生物[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。
• 参考文献:

  [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

MSDS

Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate Revision number: 1 SAFETY DATA SHEET Section1. BASE INFORMATION Product name:Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate Revision number:1 Section2. HAZARDS IDENTIFICATION Classification of the GHS Not classified PHYSICAL HAZARDS HEALTH HAZARDSNot classified Not classified ENVIRONMENTAL HAZARDS GHS label elements None Pictograms or hazard symbols Signal wordNo signal word None Hazard statement Precautionary statementsNone Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Substance Component(s):Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate Percent:>98.0%(T) 4299-03-0 CAS Number: Chemical Formula:C13H19N5O2·HCl·H2O Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell. Skin contact:Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation or rash occurs: Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Get medical advice/attention if you feel unwell. Rinse mouth. Ingestion: Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air- tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, foam, water spray, carbon dioxide. media: Take care as it may decompose upon combustion or in high temperatures to Specific hazards: generate poisonous fume. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing Specific methods: method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate Section5. FIRE-FIGHTING MEASURES Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Use personal protective equipment. Keep people away from and upwind of spill/leak. Personal precautions, protective equipment and Entry to non-involved personnel should be controlled around the leakage area by emergency procedures: roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling:Avoid contact with skin, eyes and clothing. Storage Storage conditions:Keep container tightly closed. Store in a cool and dark place. Store away from incompatible materials such as oxidizing agents. Packaging material:Law is followed. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust as possible so that workers should not be exposed directly. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator. Follow local and national regulations. Hand protection:Protective gloves. Eye protection:Safety glasses. A face-shield, if the situation requires. Skin and body protection: Protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Solid Physical state (20°C): Form:crystal - powder Color:White - Slightly pale yellow Odor:No data available pH: No data available Melting point/freezing point:No data available Boiling Point/Range:No data available Flash Point:No data available Explosive limits Lower:No data available Upper:No data available Density:No data available Solubility:No data available Section10. STABILITY AND REACTIVITY Stable under proper conditions. Stability: Reactivity:No special reactivity has been reported. Incompartible materials: oxidizing agents Hazardous Decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen chloride Products: Nα-Benzoyl-L-argininamide Hydrochloride Monohydrate Section11. TOXICOLOGICAL INFORMATION Acute Toxicity:No data available Skin corrosion/irritation: No data available Serious eyeNo data available damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: IARC =No data available NTP =No data available Reproductive toxicity:No data available Section12. ECOLOGICAL INFORMATION Ecotoxicity: No data available Fish: Crustacea:No data available No data available Algae: Persistence / degradability: No data available No data available Bioaccumulative potential(BCF): Mobillity in soil log Pow:No data available No data available Soil adsorption (Koc): Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations Not Listed UN-No: Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境

安全

• 危害码 (欧洲): C
• 风险声明 (欧洲): R34:Causes burns.
• 安全声明 (欧洲): S26-S36/37/39-S45
• 危险品运输编码: UN 3261 8/PG 2
• WGK德国: 3
• 包装等级: II
• 危险类别: 8
• 海关编码: 2925290090

海关

海关编码	2925290090
中文概述	2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%