92-67-1

92-67-1结构式

常用中文名：4-氨基联苯
常用英文名：4-Aminobiphenyl
CAS号：92-67-1
分子式：C₁₂H₁₁N
分子量：169.222
相关类别：化学试剂有机试剂芳烃
发布时间：2018-09-13 06:40:26
更新时间：2024-01-09 15:41:40
1.染料和农药中间体。还用于制造闪烁剂对三联苯。制造染料。癌症研究。

2.用于有机合成；用作橡胶防老剂。

中文名	4-氨基联苯
英文名	biphenyl-4-amine
中文别名	4-联苯胺苯基苯胺 4-氨基联苯酚酯
英文别名	Biphenyl-4-amine [1,1'-Phenyl]-4-amine 4-Amino-p-biphenyl MFCD00007879 4-Aminobiphenyl 4-phenylaniline EINECS 202-177-1 [1,1'-Biphenyl]-4-amine 4-Biphenylamine

密度	1.1±0.1 g/cm3
沸点	302.0±0.0 °C at 760 mmHg
熔点	52-54 °C(lit.)
分子式	C₁₂H₁₁N
分子量	169.222
闪点	152.2±14.6 °C
精确质量	169.089142
PSA	26.02000
LogP	2.77
外观性状	褐色黄色固体
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.619
储存条件	储存注意事项储存于阴凉、通风的库房。远离火种、热源。包装密封。应与氧化剂、酸类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
稳定性	1.稳定性稳定 2.禁配物强氧化剂、酸类、酰基氯、酸酐 3.避免接触的条件受热 4.聚合危害不聚合
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:1 4.可旋转化学键数量:1 5.互变异构体数量:无 6.拓扑分子极性表面积26 7.重原子数量:13 8.表面电荷:0 9.复杂度:141 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：棕褐色粉末 2.熔点（℃）：52~54 3.沸点（℃）：191（2.0kPa） 4.相对密度（水=1）：1.16（20℃） 5.饱和蒸气压（kPa）：2.0（191℃） 6.临界压力（MPa）：3.29 7.辛醇/水分配系数：2.80 8.闪点（℃）：110 9.引燃温度（℃）：450 10.爆炸上限（%）：5.2 11.爆炸下限（%）：0.7 12.溶解性：微溶于水，溶于乙醇、乙醚和氯仿。

国标编号:	61802
ＣＡＳ:	92-67-1
中文名称:	4-氨基联苯
英文名称:	4-Aminobiphenyl；p-aminophenylbenzene
别名:	对氨基联苯；对氨基苯胺；苯基苯胺〉
分子式:	C₁₂H₁₁N；C₆H₅C₆H₄NH₂
分子量:	169.23
熔点:	52～54℃ 沸点：191℃
密度:
蒸汽压:	〉110℃
溶解性:	微溶于水，溶于乙醇、乙醚和氯仿
稳定性:	稳定
外观与性状:	棕褐色粉末
危险标记:	15(毒害品)
用途:	用于有机合成

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：4-氨基联苯有刺激作用。吸收后导致形成高铁血红蛋白而引起发绀。吸入、摄入或经皮肤吸收可能致死。

二、毒理学资料及环境行为

急性毒性：LD50500mg/kg(大鼠经口)；LD50690mg/kg(兔经口)
致突变性：微生物致突变：鼠伤寒沙门氏菌10ug/ 皿。微粒体致突变：鼠伤寒沙门氏菌50ug/皿。
致癌性：IARC致癌性评论：人类致癌物质。

危险特性：遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。

3.现场应急监测方法:
　

4.实验室监测方法:
色谱/质谱法《水和有害废物的监测分析方法》周文敏等编译
高效液相色谱法，参照《分析化学手册》(第四分册，色谱分析)，化学工业出版社

5.环境标准:
欧洲经济共同体(1982)
氨基联苯的量≥1kg，则列为危险品，负责人应采取一切措施，防止发生重大事故，限制事故对人及环境的影响。

6.应急处理处置方法:
一、泄漏应急处理

隔离泄漏污染区，周围设避免扬尘，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，避免扬尘，小心扫起，置于袋中转移至安全场所。如大量泄漏，收集回收或无害处理后废弃。

二、防护措施

呼吸系统防护：空气中浓度较高时，佩带防毒面具。紧急事态抢救或逃生时，应该佩戴自给式呼吸器。
眼睛防护：戴化学安全防护眼镜。
防护服：穿紧袖工作服，长统胶鞋。
手防护：戴橡皮手套。
其它：工作现场禁止吸烟、进食和饮水。及时换洗工作服。工作前不饮酒，用温水洗澡。进行就业前和定期的体检。

三、急救措施

皮肤接触：立即脱去污染的衣着，用肥皂水及清水彻底冲洗。注意手、足和指甲等部位。
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水冲洗。
吸入：迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：误服者给漱口，饮水，洗胃后口服活性炭，再给以导泻。就医。

灭火方法：雾状水、二氧化碳、砂土、干粉、泡沫。

毒理学数据:

1.急性毒性

LD50：500mg/kg（大鼠经口）；205mg/kg（小鼠经口）；690mg/kg（兔经口）

2.刺激性无资料

3.致突变性微生物致突变：鼠伤寒沙门菌2μg/皿。程序外DNA合成：人肝100μg/L。DNA损伤：人淋巴细胞500μmol/L（2h）。DNA加合物：小鼠经口80mg/kg。

4.致癌性 IARC致癌性评论：组1，对人类是致癌物。

生态学数据:

1.生态毒性暂无资料

2.生物降解性

好氧生物降解（h）：24~168

厌氧生物降解（h）：96~672

3.非生物降解性

水中光氧化半衰期（h）：62.4~3480

空气中光氧化半衰期（h）：0.6~6

4.生物富集性 BCF：32（理论）

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU8925000

CHEMICAL NAME :: 4-Biphenylamine

CAS REGISTRY NUMBER :: 92-67-1

BEILSTEIN REFERENCE NO. :: 0386533

LAST UPDATED :: 199712

DATA ITEMS CITED :: 89

MOLECULAR FORMULA :: C12-H11-N

MOLECULAR WEIGHT :: 169.24

WISWESSER LINE NOTATION :: ZR DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 205 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4560 mg/kg/44W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1520 mg/kg/39W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 216 mg/kg/3D-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5000 mg/kg/W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5580 mg/kg/4Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 8200 mg/kg/90W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 8200 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9600 mg/kg/3Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 8400 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 14 gm/kg/3Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5460 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rabbit Liver

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3120,1983 *** REVIEWS *** ACGIH TLV-Confirmed human carcinogen (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,74,1972 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,74,1972 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 28,151,1982 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,91,1987 TOXICOLOGY REVIEW KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 12(2),85,1976 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,10,1971 OSHA PEL (Gen Indu):see CFR 29,1910.1011 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):see CFR 29,1926.1111 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):see CFR 29,1915.1011 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1011,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.001 ppm;STEL 0.007 ppm;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Skin;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 4-AMINODIPHENYL-air:CA use 29 CFR 1910.1011 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

符号	GHS07, GHS08
信号词	Danger
危害声明	H302-H350
警示性声明	P201-P308 + P313
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T:Toxic;
风险声明 (欧洲)	R45;R22
安全声明 (欧洲)	S53-S45
危险品运输编码	UN 3077 9/PG 3
WGK德国	3
RTECS号	DU8925000
包装等级	I
危险类别	6.1(a)
海关编码	2921499020

上游产品 9
106-47-8 98-80-6 540-37-4 106-40-1
92-66-0 5122-94-1 71-43-2 17763-78-9
2633-57-0
下游产品 10
108779-67-5 103012-26-6 109496-98-2 32228-99-2
63344-48-9 92-86-4 92-93-3 92-95-5
92-69-3 92-66-0

海关编码	2921499020
中文概述	2921499020 4-氨基联苯。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	X.有毒化学品环境管理放行通知单
Summary	2921499020 [1,1'-biphenyl]-4-amine。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

92-67-1	135-68-2
850-52-2	2198-59-6
3457-98-5	41738-70-9
1355992-59-4	2252187-21-4
1204-41-7	57964-45-1