69004-04-2

• 常用中文名：妥曲珠利砜
• 常用英文名：Ponazuril
• CAS号：69004-04-2
• 分子式：C₁₈H₁₄F₃N₃O₆S
• 分子量：457.38000
• 相关类别： 化学试剂 有机试剂 砜、亚砜类化合物
• 发布时间：2018-08-09 17:19:33
• 更新时间：2024-01-10 15:58:59
• Toltrazuril sulfone是抗寄生虫化合物,对球虫亚纲有效。

名称

• 中文名: 妥曲珠利砜
• 英文名: 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
• 中文别名: 1-甲基-3-{3-甲基-4-[4-(三氟甲基磺酰)苯氧基]苯基}-1,3,5-三嗪-2,4,6(1H,3H,5H)-三酮; 托曲珠利砜; 帕托珠利
• 英文别名: Toltrazuril sulfone; Ponazuril; 1-methyl-3-[3-methyl-4-(4-trifluoromethanesulfonyl-phenoxy)-phenyl]-[1,3,5]triazinane-2,4,6-trione; Marquis; toltrazuril; Ponazuril [INN]; 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; UNII-JPW84AS66U; Toltrazuril (sulfone)

物化性质

• 密度: 1.507g/cm3
• 熔点: 242°
• 分子式: C₁₈H₁₄F₃N₃O₆S
• 分子量: 457.38000
• 精确质量: 457.05600
• PSA: 128.61000
• LogP: 2.69950
• 折射率: 1.572

生物活性

• 描述: Toltrazuril sulfone是抗寄生虫化合物,对球虫亚纲有效。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Pharmacokinetics of ponazuril after oral administration to healthy Ilamas (Lama glama) By Prado, Maria E.; Ryman, Josiah T.; Boileau, Melanie J.; Martin-Jimenez, Tomas; Meibohm, Bernd From American Journal of Veterinary Research (2011), 72(10), 1386-1389

  [2]. Dirikolu L, Karpiesiuk W, Lehner AF, Tobin T. Toltrazuril sulfone sodium salt: synthesis, analytical detection, and pharmacokinetics in the horse. J Vet Pharmacol Ther. 2012 Jun;35(3):265-74. doi: 10.1111/j.1365-2885.2011.01315.x.

  [3]. Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI. Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. J Vet Med Sci. 2010 Aug;72(8):1085-7.

  [4]. Dirikolu L, Yohn R, Garrett EF, Chakkath T, Ferguson DC. Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle. J Vet Pharmacol Ther. 2009 Jun;32(3):280-8.

  [5]. Dirikolu L, Karpiesiuk W, Lehner AF, Hughes C, Granstrom DE, Tobin T. Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide. J Vet Pharmacol Ther. 2009 Aug;32(4):368-78.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport