103300-74-9

• 常用中文名：他替瑞林
• 常用英文名：Taltirelin
• CAS号：103300-74-9
• 分子式：C₁₇H₂₃N₇O₅
• 分子量：405.408
• 相关类别： 生物化工 多肽
• 发布时间：2018-03-16 08:00:00
• 更新时间：2024-01-02 14:46:17
• Taltirelin(TA0910)是口服活性的TRH类似物,能与鼠脑中TRH受体结合。

名称

• 中文名: 他替瑞林
• 英文名: Taltirelin
• 中文别名: (4S)-N-[(2S)-1-[(2S)-2-氨基甲酰基吡咯烷-1-基]-3-(3H-咪唑-4-基)-1-氧代丙-2-基]-1-甲基-2,6-二氧代-1,3-二氮杂己环-4-甲酰胺
• 英文别名: Taltirelin; (-)-N-[[(S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide; L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-; N-{[(4S)-1-Methyl-2,6-dioxohexahydro-4-pyrimidinyl]carbonyl}-L-histidyl-L-prolinamide; (4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide; N-{[(4S)-1-Methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide; TA-0910; Taltirelin Acetate

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 72-75°
• 分子式: C₁₇H₂₃N₇O₅
• 分子量: 405.408
• 精确质量: 405.176056
• PSA: 170.59000
• LogP: -4.09
• 折射率: 1.612
• 储存条件: 2-8℃

生物活性

• 描述: Taltirelin(TA0910)是口服活性的TRH类似物,能与鼠脑中TRH受体结合。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Fukuchi, I., et al., Effects of taltirelin hydrate (TA-0910), a novel thyrotropin-releasing hormone analog, on in vivo dopamine release and turnover in rat brain. Arzneimittelforschung, 1998. 48(4): p. 353-9.

  [2]. Asai, H., et al., Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacol Biochem Behav, 2005. 82(4): p. 646-51.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TW3578050 CAS REGISTRY NUMBER : 103300-74-9 LAST UPDATED : 199212 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C17-H23-N7-O5.4H2-O MOLECULAR WEIGHT : 477.55 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1590 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2130,1990