他替瑞林

• 常用名: 他替瑞林
• 英文名: Taltirelin
• CAS号: 103300-74-9
• 分子量: 405.408
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₇H₂₃N₇O₅
• 熔点: 72-75°
• 闪点: N/A

他替瑞林用途

Taltirelin(TA0910)是口服活性的TRH类似物,能与鼠脑中TRH受体结合。

他替瑞林名称

• 中文名: 他替瑞林
• 英文名: Taltirelin
• 中文别名: (4S)-N-[(2S)-1-[(2S)-2-氨基甲酰基吡咯烷-1-基]-3-(3H-咪唑-4-基)-1-氧代丙-2-基]-1-甲基-2,6-二氧代-1,3-二氮杂己环-4-甲酰胺

他替瑞林生物活性

• 描述: Taltirelin(TA0910)是口服活性的TRH类似物,能与鼠脑中TRH受体结合。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Fukuchi, I., et al., Effects of taltirelin hydrate (TA-0910), a novel thyrotropin-releasing hormone analog, on in vivo dopamine release and turnover in rat brain. Arzneimittelforschung, 1998. 48(4): p. 353-9.

  [2]. Asai, H., et al., Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacol Biochem Behav, 2005. 82(4): p. 646-51.

他替瑞林物理化学性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 72-75°
• 分子式: C₁₇H₂₃N₇O₅
• 分子量: 405.408
• 精确质量: 405.176056
• PSA: 170.59000
• LogP: -4.09
• InChIKey: LQZAIAZUDWIVPM-SRVKXCTJSA-N
• SMILES: CN1C(=O)CC(C(=O)NC(Cc2cnc[nH]2)C(=O)N2CCCC2C(N)=O)NC1=O
• 折射率: 1.612
• 储存条件: 2-8℃

他替瑞林毒性和生态

他替瑞林靶点实验

查看更多实验

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa... 来源：824 靶标：AR protein [Homo sapiens] External Id：MDAN535

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign... 来源：824 靶标：N/A External Id：MDAV150

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel... 来源：824 靶标：RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein External Id：ELG271

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：thyroid hormone receptor beta isoform 2 [Rattus norvegicus] External Id：TRN186

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：N/A External Id：TRV455

实验名称：S16 Schwann cell viability assay (CellTiter-Glo assay) 来源：NCGC 靶标：N/A External Id：cmt-p4-fda-celltiter_regid

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他替瑞林英文别名

• Taltirelin
• (-)-N-[[(S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
• N-{[(4S)-1-Methyl-2,6-dioxohexahydro-4-pyrimidinyl]carbonyl}-L-histidyl-L-prolinamide
• (4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide
• N-{[(4S)-1-Methyl-2,6-dioxohexahydropyrimidin-4-yl]carbonyl}-L-histidyl-L-prolinamide
• TA-0910
• Taltirelin Acetate