67306-03-0

• 常用中文名：丁苯吗琳
• 常用英文名：fenpropimorph
• CAS号：67306-03-0
• 分子式：C₂₀H₃₃NO
• 分子量：303.48200
• 相关类别： 化学农药原药 杀菌剂 其他杀菌剂
• 发布时间：2018-09-05 20:43:05
• 更新时间：2024-01-02 21:41:56
• 吗啉类杀菌剂，具有保护、治疗、内吸作用。甾醇还原抑制剂，可用于禾谷类作物、豆类、甜菜的白粉病、黑粉病、锈病、棉花立枯病，谷类黑穗病等。推荐药量7.5g有效成分/100m²。

名称

• 中文名: 丁苯吗啉
• 英文名: 4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
• 中文别名: 丁苯吗琳; 顺-4-叔丁基苯基(-2-甲基丙基)-2,6-二甲基吗啉; (±)顺-4-(3-(4-特丁基苯基)-2-甲基丙基)-2,6-二甲基吗啉
• 英文别名: FUNBAS; MISTRAL T; FENPROPIMORPH; forbel750; MISTRAL; MILDOFIX; BAS 421F; CORBEL

物化性质

• 密度: 0.928 g/cm3
• 沸点: 392.7ºC at 760 mmHg
• 熔点: 25°C
• 分子式: C₂₀H₃₃NO
• 分子量: 303.48200
• 闪点: 115.6ºC
• 精确质量: 303.25600
• PSA: 12.47000
• LogP: 4.20980
• 折射率: 1.489
• 储存条件: 0-6°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QE2060000 CHEMICAL NAME : Morpholine, 4-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)-2, 6-dimethyl- CAS REGISTRY NUMBER : 67306-03-0 LAST UPDATED : 199512 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C20-H33-N-O MOLECULAR WEIGHT : 303.54 WISWESSER LINE NOTATION : T6N DOTJ A1Y1&1R DX1&1&1& C1 E1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(254),33,1988 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2900 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A201,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,541,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5890 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(254),33,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,541,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 17780 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(254),33,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - domestic DOSE/DURATION : 39 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(254),33,1988

安全

• 危险品运输编码: UN 2902
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 29349990

合成路线

141-91-3 13586-68-0 ~% 67306-03-0

文献：Forsyth, Stewart A.; Gunaratne, H. Q. Nimal; Hardacre, Christopher; McKeown, Angela; Rooney, David W. Organic Process Research and Development, 2006 , vol. 10, # 1 p. 94 - 102

141-91-3 80-54-6 ~% 67306-03-0

文献：Forsyth, Stewart A.; Gunaratne, H. Q. Nimal; Hardacre, Christopher; McKeown, Angela; Rooney, David W. Organic Process Research and Development, 2006 , vol. 10, # 1 p. 94 - 102

67305-99-1 ~% 67306-03-0

文献：Hoffmann-La Roche Inc. Patent: US4241058 A1, 1980 ;

35779-04-5 ~% 67306-03-0

文献：Forsyth, Stewart A.; Gunaratne, H. Q. Nimal; Hardacre, Christopher; McKeown, Angela; Rooney, David W. Organic Process Research and Development, 2006 , vol. 10, # 1 p. 94 - 102

上下游产品

上游产品  5
141-91-3 13586-68-0 80-54-6 67305-99-1
35779-04-5
下游产品  0

制备

Vilsmeier反应 以二甲基甲酰胺为溶剂，20℃时将三氯氧磷加入到溶剂中，升温，于70～80℃滴加4-特丁基苯乙酮，反应5h，反应毕，用30%氢氧化钠处理，得含量96%的4-特丁基苯基-1-氯代-2-甲基丙烯醛。
还原反应 4-特丁基苯基-1-氯代-2-甲基丙烯醛在钯/碳催化下加氢还原制得4-特丁基苯基异丁醛。
丁苯吗啉的合成 4-特丁基苯基异丁醛与2，6-二甲基吗啉反应合成丁苯吗啉。