893440-50-1

• 常用中文名：3-氨基-2-甲氧基吡啶-5-硼酸频哪醇酯
• 常用英文名：3-Amino-2-methoxypyridine-5-boronic acid pinacol ester
• CAS号：893440-50-1
• 分子式：C₁₂H₁₉BN₂O₃
• 分子量：250.102
• 发布时间：2018-12-26 17:42:25
• 更新时间：2024-01-04 18:19:08

名称

• 中文名: 3-氨基-2-甲氧基吡啶-5-硼酸频哪醇酯
• 英文名: 3-Amino-2-methoxypyridine-5-boronic acid pinacol ester
• 中文别名: 5-氨基-6-甲氧基吡啶-3-硼酸频哪醇酯; 3-氨基-2-甲氧基吡啶-5-硼酸频呐醇酯
• 英文别名: 3-Pyridinamine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; QC-4814; 2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine; 2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-ylamine; 3-Amino-2-methoxypyridine-5-boronic acid pinacol ester; 5-Amino-6-methoxypyridine-3-boronic acid pinacol ester; 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine; (5-amino-6-methoxypyridin-3-yl)boronic acid pinacol ester; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine; 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 392.3±42.0 °C at 760 mmHg
• 熔点: 144 °C
• 分子式: C₁₂H₁₉BN₂O₃
• 分子量: 250.102
• 闪点: 191.1±27.9 °C
• 精确质量: 250.148880
• PSA: 66.60000
• LogP: 1.55280
• 外观性状: 固体;White to Gray to Brown powder to crystal
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.514
• 储存条件: 2-8°C

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

合成路线

884495-39-0 73183-34-3 ~92% 893440-50-1

文献：GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun Patent: WO2012/174312 A2, 2012 ; Location in patent: Page/Page column 287 ; WO 2012/174312 A2

1083168-94-8 ~93% 893440-50-1

文献：Su, Weiguo; Zhang, Weihan; Yang, Haibin Patent: US2013/190307 A1, 2013 ; Location in patent: Paragraph 0151; 0152 ;

893440-45-4 ~95% 893440-50-1

文献：VERTEX PHARMACEUTICALS INCORPORATED Patent: WO2006/65946 A1, 2006 ; Location in patent: Page/Page column 72 ; WO 2006/065946 A1

152684-30-5 ~% 893440-50-1

文献：WO2012/32067 A1, ; WO 2012/032067 A1

73183-34-3 ~% 893440-50-1

文献：WO2012/34526 A1, ; WO 2012/034526 A1

67443-38-3 ~% 893440-50-1

文献：WO2012/32067 A1, ; WO 2012/032067 A1

上下游产品

上游产品  6
884495-39-0 73183-34-3 1083168-94-8 893440-45-4
152684-30-5 67443-38-3
下游产品  1
1083326-73-1

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%