52807-12-2

• 常用中文名：4-羟基氟吡洛芬
• 常用英文名：4'-Hydroxy Flurbiprofen
• CAS号：52807-12-2
• 分子式：C₁₅H₁₃FO₃
• 分子量：260.26000
• 发布时间：2018-10-21 19:56:07
• 更新时间：2024-01-07 09:31:39
• 4'-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen and its enantiomers (R)-flurbiprofen and (S)-flurbiprofen.

名称

• 中文名: 4-羟基氟吡洛芬
• 英文名: 4'-Hydroxy Flurbiprofen
• 中文别名: 氟比洛芬杂质G
• 英文别名: 4'-Hydroxy Flurbiprofen; 2-(4'-Hydroxy-2-fluoro-4-biphenylyl)propionic Acid; 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)propanoic acid; 2-(2-fluoro-4'-hydroxy-4-biphenylyl)propionic acid; FPH; 2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid; Flurbiprofen EP Impurity G

物化性质

• 密度: 1.288g/cm3
• 沸点: 417.6ºC at 760 mmHg
• 熔点: 177-178ºC
• 分子式: C₁₅H₁₃FO₃
• 分子量: 260.26000
• 闪点: 206.3ºC
• 精确质量: 260.08500
• PSA: 57.53000
• LogP: 3.38640
• 折射率: 1.593
• 储存条件: -20°C，密闭，干燥

安全

• 海关编码: 2922299090

合成路线

446-35-5 ~% 52807-12-2

文献：Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

78543-06-3 ~% 52807-12-2

文献：Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

749917-25-7 71597-85-8 ~% 52807-12-2

文献：Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

749917-24-6 ~% 52807-12-2

文献：Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

78543-08-5 ~% 52807-12-2

文献：Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

5104-49-4 ~% 52807-12-2

文献：Hummel, Matthew A.; Locuson, Charles W.; Gannett, Peter M.; Rock, Dan A.; Mosher, Carrie M.; Rettie, Allan E.; Tracy, Timothy S. Molecular Pharmacology, 2005 , vol. 68, # 3 p. 644 - 651

113544-38-0 ~% 52807-12-2

文献：Chen, Yao; Sun, Jianfei; Huang, Zhangjian; Liao, Hong; Peng, Sixun; Lehmann, Jochen; Zhang, Yihua Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2462 - 2470

215175-83-0 ~% 52807-12-2

文献：Chen, Yao; Sun, Jianfei; Huang, Zhangjian; Liao, Hong; Peng, Sixun; Lehmann, Jochen; Zhang, Yihua Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2462 - 2470

41635-83-0 ~% 52807-12-2

文献：The Boots Co. Patent: DE2329125 , 1974 ; Chem.Abstr., 1975 , vol. 82, # 16565

上下游产品

上游产品  9
446-35-5 78543-06-3 749917-25-7 71597-85-8
78543-08-5 5104-49-4 113544-38-0 215175-83-0
41635-83-0
下游产品  0

海关

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%