4'-Hydroxy Flurbiprofen

Modify Date: 2024-01-07 09:31:39

4'-Hydroxy Flurbiprofen Structure
4'-Hydroxy Flurbiprofen structure
Common Name 4'-Hydroxy Flurbiprofen
CAS Number 52807-12-2 Molecular Weight 260.26000
Density 1.288g/cm3 Boiling Point 417.6ºC at 760 mmHg
Molecular Formula C15H13FO3 Melting Point 177-178ºC
MSDS N/A Flash Point 206.3ºC

 Use of 4'-Hydroxy Flurbiprofen


4'-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen and its enantiomers (R)-flurbiprofen and (S)-flurbiprofen.

 Names

Name 4'-Hydroxy Flurbiprofen
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.288g/cm3
Boiling Point 417.6ºC at 760 mmHg
Melting Point 177-178ºC
Molecular Formula C15H13FO3
Molecular Weight 260.26000
Flash Point 206.3ºC
Exact Mass 260.08500
PSA 57.53000
LogP 3.38640
Index of Refraction 1.593

 Safety Information

HS Code 2922299090

 Synthetic Route

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

~%

4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

~%

4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Peretto, Ilaria; Radaelli, Stefano; Parini, Carlo; Zandi, Michele; Raveglia, Luca F.; Dondio, Giulio; Fontanella, Laura; Misiano, Paola; Bigogno, Chiara; Rizzi, Andrea; Riccardi, Benedetta; Biscaioli, Marcello; Marchetti, Silvia; Puccini, Paola; Catinella, Silvia; Rondelli, Ivano; Cenacchi, Valentina; Bolzoni, Pier Tonino; Caruso, Paola; Villetti, Gino; Facchinetti, Fabrizio; Del Giudice, Elda; Moretto, Nadia; Imbimbo, Bruno P. Journal of Medicinal Chemistry, 2005 , vol. 48, # 18 p. 5705 - 5720

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Hummel, Matthew A.; Locuson, Charles W.; Gannett, Peter M.; Rock, Dan A.; Mosher, Carrie M.; Rettie, Allan E.; Tracy, Timothy S. Molecular Pharmacology, 2005 , vol. 68, # 3 p. 644 - 651

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Chen, Yao; Sun, Jianfei; Huang, Zhangjian; Liao, Hong; Peng, Sixun; Lehmann, Jochen; Zhang, Yihua Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2462 - 2470

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: Chen, Yao; Sun, Jianfei; Huang, Zhangjian; Liao, Hong; Peng, Sixun; Lehmann, Jochen; Zhang, Yihua Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2462 - 2470

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4'-Hydroxy Flurbiprofen Structure

4'-Hydroxy Flur...

CAS#:52807-12-2

Literature: The Boots Co. Patent: DE2329125 , 1974 ; Chem.Abstr., 1975 , vol. 82, # 16565

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

4'-Hydroxy Flurbiprofen
2-(4'-Hydroxy-2-fluoro-4-biphenylyl)propionic Acid
2-(2-fluoro-4'-hydroxybiphenyl-4-yl)propanoic acid
2-(2-fluoro-4'-hydroxy-4-biphenylyl)propionic acid
FPH
2-(2-fluoro-4'-hydroxy-biphenyl-4-yl)-propionic acid
Flurbiprofen EP Impurity G
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