22090-24-0

• 常用中文名：4-哌嗪苯甲酸
• 常用英文名：4-piperidinobenzoic acid
• CAS号：22090-24-0
• 分子式：C₁₂H₁₅NO₂
• 分子量：205.253
• 相关类别： 医药中间体 杂环化合物 哌嗪类化合物
• 发布时间：2018-07-21 17:50:13
• 更新时间：2024-01-11 13:10:55

名称

• 中文名: 4-哌嗪苯甲酸
• 英文名: 4-piperidin-1-ylbenzoic acid
• 英文别名: 4-piperidylbenzoic acid; Benzoic acid, 4-(1-piperidinyl)-; 4-Piperidin-1-yl-benzoic acid; 4-piperidine-1-ylbenzoic acid; 1-(4-Carboxyphenyl)piperidine; 4-piperidinobenzoic acid; 4-Piperidino-benzoesaeure; 4-(piperidin-1-yl)benzoic acid; 4-(1-Piperidinyl)-benzoic acid; 4-(1-Piperidinyl)benzoic acid; 4-piperidin-1-ylbenzoic acid; MFCD00587602

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 388.9±25.0 °C at 760 mmHg
• 熔点: 222 - 224ºC
• 分子式: C₁₂H₁₅NO₂
• 分子量: 205.253
• 闪点: 189.0±23.2 °C
• 精确质量: 205.110275
• PSA: 40.54000
• LogP: 2.66
• 外观性状: 灰白色
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.580
• 储存条件: 2-8°C

MSDS

Name: 4-Piperidinobenzoic acid Material Safety Data Sheet Synonym: CAS: 22090-24-0 Section 1 - Chemical Product MSDS Name:4-Piperidinobenzoic acid Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 22090-24-0 4-Piperidinobenzoic acid 97+% unlisted Hazard Symbols: XN Risk Phrases: 22 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful if swallowed. Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. Inhalation: Causes respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 22090-24-0: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Off white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 222 - 224 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H15NO2 Molecular Weight: 205.26 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents, reducing agents, strong bases, amines. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 22090-24-0 unlisted. LD50/LC50: Not available. Carcinogenicity: 4-Piperidinobenzoic acid - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 22 Do not breathe dust. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 22090-24-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 22090-24-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 22090-24-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26
• 海关编码: 2933399090

合成路线

1204-85-9 ~87% 22090-24-0

文献：WYETH Patent: US2006/287522 A1, 2006 ; Location in patent: Page/Page column 54 ; US 20060287522 A1

101038-65-7 ~50% 22090-24-0

文献：Boehringer Ingelheim International GmbH Patent: US2004/242572 A1, 2004 ; Location in patent: Page/Page column 59 ;

10338-58-6 ~% 22090-24-0

文献：WO2009/43890 A1, ; Page/Page column 55-56 ; WO 2009/043890 A1

110-89-4 456-22-4 ~80% 22090-24-0

文献：Khuthier, Abdul-Hussain; Al-Mallah, Khawla Y.; Hanna, Salim Y.; Abdulla, Noor-Aldeen I. Journal of Organic Chemistry, 1987 , vol. 52, # 9 p. 1710 - 1713

110-89-4 ~% 22090-24-0

文献：Journal of the American Chemical Society, , vol. 62, p. 2995,3001

1194-02-1 ~% 22090-24-0

文献：Molecular Crystals and Liquid Crystals (1969-1991), , vol. 124, p. 269 - 276

111-24-0 150-13-0 ~% 22090-24-0

文献：Chemische Berichte, , vol. 40, p. 857

上下游产品

上游产品  8
1204-85-9 101038-65-7 10338-58-6 110-89-4
456-22-4 1194-02-1 111-24-0 150-13-0
下游产品  0

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%