453560-74-2

• 常用中文名：2-甲氧基-4-硝基-1-(三氟甲基)苯
• 常用英文名：2-Methoxy-4-nitro-1-(trifluoromethyl)benzene
• CAS号：453560-74-2
• 分子式：C₈H₆F₃NO₃
• 分子量：221.13300
• 发布时间：2018-12-29 18:04:30
• 更新时间：2024-01-02 21:22:18

名称

• 中文名: 2-甲氧基-4-硝基-1-(三氟甲基)苯
• 英文名: 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene
• 英文别名: 5-nitro-2-trifluoromethylanisole; methoxynitrotrifluoromethylbenzene; AD-0764; 2-methoxy-4-nitro-1-trifluoromethyl-benzene

物化性质

• 分子式: C₈H₆F₃NO₃
• 分子量: 221.13300
• 精确质量: 221.03000
• PSA: 55.05000
• LogP: 3.14540
• 储存条件: 室温

合成路线

2314-97-8 5458-84-4 ~43% 453560-74-2

文献：Potashman, Michele H.; Bready, James; Coxon, Angela; Demelfi Jr., Thomas M.; DiPietro, Lucian; Doerr, Nicholas; Elbaum, Daniel; Estrada, Juan; Gallant, Paul; Germain, Julie; Gu, Yan; Harmange, Jean-Christophe; Kaufman, Stephen A.; Kendall, Rick; Kim, Joseph L.; Kumar, Gondi N.; Long, Alexander M.; Neervannan, Seshadri; Patel, Vinod F.; Polverino, Anthony; Rose, Paul; Van Der Plas, Simon; Whittington, Douglas; Zanon, Roger; Zhao, Huilin Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4351 - 4373

5458-84-4 81290-20-2 ~73% 453560-74-2

文献：Talamas, Francisco X.; Abbot, Sarah C.; Anand, Shalini; Brameld, Ken A.; Carter, David S.; Chen, Jun; Davis, Dana; De Vicente, Javier; Fung, Amy D.; Gong, Leyi; Harris, Seth F.; Inbar, Petra; Labadie, Sharada S.; Lee, Eun K.; Lemoine, Remy; Le Pogam, Sophie; Leveque, Vincent; Li, Jim; McIntosh, Joel; Najera, Isabel; Park, Jaehyeon; Railkar, Aruna; Rajyaguru, Sonal; Sangi, Michael; Schoenfeld, Ryan C.; Staben, Leanna R.; Tan, Yunchou; Taygerly, Joshua P.; Villasenor, Armando G.; Weller, Paul E. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1914 - 1931

1514-87-0 5458-84-4 ~51% 453560-74-2

文献：Brotherton-Pleiss, Christine E.; Caroon, Joan Marie; Lopez-Tapia, Francisco Javier Patent: US2010/160388 A1, 2010 ; Location in patent: Page/Page column 64-65 ; US 20100160388 A1

680-15-9 77337-82-7 ~% 453560-74-2

文献：VERTEX PHARMACEUTICALS INCORPORATED Patent: US2010/168094 A1, 2010 ; Location in patent: Page/Page column 69; 70 ; US 20100168094 A1

5458-84-4 ~% 453560-74-2

文献：AMGEN INC Patent: WO2004/85425 A1, 2004 ; Location in patent: Page 98-99 ; WO 2004/085425 A1

1448037-95-3 81290-20-2 ~64% 453560-74-2

文献：Hafner, Andreas; Braese, Stefan Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 996 - 1000

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