2-Methoxy-4-nitro-1-(trifluoromethyl)benzene

Modify Date: 2024-01-02 21:22:18

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure
2-Methoxy-4-nitro-1-(trifluoromethyl)benzene structure
Common Name 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene
CAS Number 453560-74-2 Molecular Weight 221.13300
Density N/A Boiling Point N/A
Molecular Formula C8H6F3NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name 2-Methoxy-4-nitro-1-(trifluoromethyl)benzene
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C8H6F3NO3
Molecular Weight 221.13300
Exact Mass 221.03000
PSA 55.05000
LogP 3.14540

 Synthetic Route

~43%

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure

2-Methoxy-4-nit...

CAS#:453560-74-2

Literature: Potashman, Michele H.; Bready, James; Coxon, Angela; Demelfi Jr., Thomas M.; DiPietro, Lucian; Doerr, Nicholas; Elbaum, Daniel; Estrada, Juan; Gallant, Paul; Germain, Julie; Gu, Yan; Harmange, Jean-Christophe; Kaufman, Stephen A.; Kendall, Rick; Kim, Joseph L.; Kumar, Gondi N.; Long, Alexander M.; Neervannan, Seshadri; Patel, Vinod F.; Polverino, Anthony; Rose, Paul; Van Der Plas, Simon; Whittington, Douglas; Zanon, Roger; Zhao, Huilin Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4351 - 4373

~73%

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure

2-Methoxy-4-nit...

CAS#:453560-74-2

Literature: Talamas, Francisco X.; Abbot, Sarah C.; Anand, Shalini; Brameld, Ken A.; Carter, David S.; Chen, Jun; Davis, Dana; De Vicente, Javier; Fung, Amy D.; Gong, Leyi; Harris, Seth F.; Inbar, Petra; Labadie, Sharada S.; Lee, Eun K.; Lemoine, Remy; Le Pogam, Sophie; Leveque, Vincent; Li, Jim; McIntosh, Joel; Najera, Isabel; Park, Jaehyeon; Railkar, Aruna; Rajyaguru, Sonal; Sangi, Michael; Schoenfeld, Ryan C.; Staben, Leanna R.; Tan, Yunchou; Taygerly, Joshua P.; Villasenor, Armando G.; Weller, Paul E. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1914 - 1931

~51%

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure

2-Methoxy-4-nit...

CAS#:453560-74-2

Literature: Brotherton-Pleiss, Christine E.; Caroon, Joan Marie; Lopez-Tapia, Francisco Javier Patent: US2010/160388 A1, 2010 ; Location in patent: Page/Page column 64-65 ; US 20100160388 A1

~%

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure

2-Methoxy-4-nit...

CAS#:453560-74-2

Literature: VERTEX PHARMACEUTICALS INCORPORATED Patent: US2010/168094 A1, 2010 ; Location in patent: Page/Page column 69; 70 ; US 20100168094 A1

~%

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure

2-Methoxy-4-nit...

CAS#:453560-74-2

Literature: AMGEN INC Patent: WO2004/85425 A1, 2004 ; Location in patent: Page 98-99 ; WO 2004/085425 A1

~64%

2-Methoxy-4-nitro-1-(trifluoromethyl)benzene Structure

2-Methoxy-4-nit...

CAS#:453560-74-2

Literature: Hafner, Andreas; Braese, Stefan Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 996 - 1000

 Synonyms

5-nitro-2-trifluoromethylanisole
methoxynitrotrifluoromethylbenzene
AD-0764
2-methoxy-4-nitro-1-trifluoromethyl-benzene