405175-79-3

• 常用中文名：(R)-4-N-Cbz-哌嗪-2-甲酸甲酯
• 常用英文名：(R)-4-N-Cbz-Piperazine-2-carboxylic acid methyl ester
• CAS号：405175-79-3
• 分子式：C₁₄H₁₈N₂O₄
• 分子量：278.304
• 发布时间：2018-12-11 20:26:40
• 更新时间：2026-08-08 09:10:19

名称

• 中文名: (R)-4-N-Cbz-哌嗪-2-甲酸甲酯
• 英文名: (R)-1-Benzyl 3-methyl piperazine-1,3-dicarboxylate
• 中文别名: (R)-4-n-cbz-哌嗪-2-羧酸甲酯; R-4-CBZ-2-哌嗪甲酸甲酯; 1-苄基-3-甲基(R)-哌嗪-1,3-二甲酸酯; (R)-1-苄基 3-甲基 哌嗪-1,3-二甲酸酯; (3R)-1,3-哌嗪二甲酸 3-甲酯 1-苄酯; (R)-4-N-CBZ-哌嗪-2-甲酸甲酯; (R)-4-N-CBZ-3-哌嗪甲酸甲酯
• 英文别名: (R)-4-N-Cbz-piperazine-3-cboxylic acid methyl ester; 1-Benzyl 3-methyl (R)-piperazine-1,3-dicboxylate; 1,3-Piperazinedicboxylic acid, 3-methyl 1-(phenylmethyl) ester, (3R); (2R)-4-[(Benzyloxy)carbonyl]-2-methyl-2-piperazinecarboxylic acid; (3R)-1,3-Piperazinedicboxylic acid 3-methyl 1-(phenylmethyl) ester; REF DUPL: (R)-4-N-Cbz-piperazine-2-cboxylic acid methyl ester; (R)-4-Cbz-piperazine-2-cboxylic acid methyl ester; (R)-4-N-CBZ-PIPERAZINE-2-CBOXYLIC ACID METHYL ESTER-HCl; 1-benzyl 3-Methyl (3R)-piperazine-1,3-dicboxylate; 1-Benzyl 3-methyl (3R)-1,3-piperazinedicarboxylate; Methyl (R)-4-N-Cbz-piperazine-3-cboxylate; 1-O-benzyl 3-O-methyl (3R)-piperazine-1,3-dicarboxylate; 1-Benzyl 3-methyl (3R)-piperazine-1,3-dicarboxylate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 459.2±45.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂O₄
• 分子量: 278.304
• 闪点: 231.5±28.7 °C
• 精确质量: 278.126648
• PSA: 67.87000
• LogP: 1.42
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.556

合成路线

126330-92-5 ~% 405175-79-3

文献：Hoekstra, William J.; Maryanoff, Bruce E.; Damiano, Bruce P.; Andrade-Gordon, Patricia; Cohen, Judith H.; Costanzo, Michael J.; Haertlein, Barbara J.; Hecker, Leonard R.; Hulshizer, Becky L.; Kauffman, Jack A.; Keane, Patricia; McComsey, David F.; Mitchell, John A.; Scott, Lorraine; Shah, Rekha D.; Yabut, Stephen C. Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5254 - 5265

501-53-1 ~% 405175-79-3

文献：Hoekstra, William J.; Maryanoff, Bruce E.; Damiano, Bruce P.; Andrade-Gordon, Patricia; Cohen, Judith H.; Costanzo, Michael J.; Haertlein, Barbara J.; Hecker, Leonard R.; Hulshizer, Becky L.; Kauffman, Jack A.; Keane, Patricia; McComsey, David F.; Mitchell, John A.; Scott, Lorraine; Shah, Rekha D.; Yabut, Stephen C. Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5254 - 5265

126330-91-4 ~% 405175-79-3

文献：Hoekstra, William J.; Maryanoff, Bruce E.; Damiano, Bruce P.; Andrade-Gordon, Patricia; Cohen, Judith H.; Costanzo, Michael J.; Haertlein, Barbara J.; Hecker, Leonard R.; Hulshizer, Becky L.; Kauffman, Jack A.; Keane, Patricia; McComsey, David F.; Mitchell, John A.; Scott, Lorraine; Shah, Rekha D.; Yabut, Stephen C. Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5254 - 5265

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