317366-82-8

• 常用中文名：β-淀粉样肽(42-1)(人)
• 常用英文名：Amyloid β-Protein (42-1)
• CAS号：317366-82-8
• 分子式：C₂₀₃H₃₁₁N₅₅O₆₀S
• 分子量：4514.106
• 相关类别： 多肽产品
• 发布时间：2018-03-26 08:00:00
• 更新时间：2026-07-02 15:40:23
• Amyloid β Peptide (42-1)(human) 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。淀粉样蛋白 β 肽 (1-42) 是由 42 个氨基酸组成的肽,其在阿尔茨海默病的发病机制中起关键作用。

名称

• 中文名: 淀粉样蛋白
• 英文名: Amyloid beta-Protein (42-1) Trifluoroacetate
• 中文别名: AMYLOID 尾 PTIDE (HUMAN); AMYLOID Β PROTEIN FRAGMENT ,HUMAN 人Β-淀粉样多肽; Β淀粉样肽; Β-淀粉样蛋白肽; Β-淀粉样蛋白,人; 淀粉Β-蛋白; beta-蛋白质 (42-1); Β淀粉样蛋白; BETA-AMYLOID多肽 (HUMAN),INACTIVE CONTROL; Β-淀粉样多肽; 三氟乙酸盐
• 英文别名: Ptide (human); ALA-ILE-VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-G-PHE-GLU-ALA-ASP: AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD; AMyloid beta huMan; β-Amyloid （human）TFA; PEPTIDE WITH REVERSED SEQUENCE OF AMYLOID BETA-PROTEIN (HUMAN, 1-42) TRIFLUOROACETATE; Amyloid β-Protein; Amyloid β-peptide (42-1) (human); Amyloid β-Protein (HFIP-treated); AMYLOID BETA-PROTEIN (HUMAN, ) TRIFLUOROACETATE; b-Amyloid (42-1); AMyloid b-Protein; β-Amyloid ptide; AMYLOID BETA-PROTEIN (HUMAN, 1-42) TRIFLUOROACETATE; beta-Amyloid Ptide (human), Inactive control; PTIDE WITH REVERSED SEQUENCE OF AMYLOID BETA-PROTEIN (HUMAN, ) TRIFLUOROACETATE; AMYLOID BETA-PROTEIN TRIFLUOROACETATE; ALA-ILE VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-G-PHE-GLU-ALA-ASP TRIFLUOROACETATE; L-Alanyl-L-isoleucyl-L-valyl-L-valylglycylglycyl-L-valyl-L-methionyl-L-leucylglycyl-L-isoleucyl-L-isoleucyl-L-alanylglycyl-L-lysyl-L-aspaginyl-L-serylglycyl-L-valyl-L-α-asptyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-phenylalanyl-L-valyl-L-leucyl-L-lysyl-L-glutaminyl-L-histidyl-L-histidyl-L-valyl-L-α-glutamyl-L-tyrosylglycyl-L-seryl-L-α-asptyl-L-histidyl-L-ginyl-L-phenylalanyl-L-α-glutamyl-L-alanyl-L-asptic acid; Amyloid β Peptide (42-1)(human); ALA-ILE VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-ARG-PHE-GLU-ALA-ASP TRIFLUOROACETATE; AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE; Amyloid β-ptide (human); Amyloid b-ptide (human); ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA TRIFLUOROACETATE; ALA-ILE-VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-G-PHE-GLU-ALA-ASP; Amyloid beta protein fragment; β-Amyloid , human; H-Ala-Ile-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-g-Phe-Glu-Ala-Asp-OH; b-Amyloid; β-Amyloid; Amyloid β-Protein (0.1mg vial); AMYLOID BETA-PROTEIN TRIFLUOROACETATE //BP; Amyloid β Ptide (human) (AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD); ASP-ALA-GLU-PHE-G-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA TRIFLUOROACETATE; Amyloid β Ptide (human)

物化性质

• 分子式: C₂₀₃H₃₁₁N₅₅O₆₀S
• 分子量: 4514.106
• 精确质量: 4513.276
• 储存条件: -20°C，密闭，干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:62

  3.氢键受体数量:68

  4.可旋转化学键数量:151

  5.互变异构体数量:1001

  6.拓扑分子极性表面积1850

  7.重原子数量:319

  8.表面电荷:0

  9.复杂度:11000

  10.同位素原子数量:0

  11.确定原子立构中心数量:36

  12.不确定原子立构中心数量:3

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Amyloid β Peptide (42-1)(human) 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。淀粉样蛋白 β 肽 (1-42) 是由 42 个氨基酸组成的肽,其在阿尔茨海默病的发病机制中起关键作用。
• 相关类别:
  信号通路 >> 神经信号通路 >> β淀粉样蛋白
  研究领域 >> 神经疾病
  多肽产品
• 参考文献:

  [1]. Schilling T, et al. Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia. J Cell Physiol. 2011 Dec;226(12):3295-302.