942999-61-3

• 常用中文名：DGAT-1抑制剂2
• 常用英文名：DGAT-1 inhibitor 2
• CAS号：942999-61-3
• 分子式：C₂₄H₂₈N₄O₃
• 分子量：420.50400
• 相关类别： 信号通路 代谢酶/蛋白酶 酰基转移酶
• 发布时间：2018-12-28 07:41:50
• 更新时间：2026-06-30 14:31:58
• DGAT-1 inhibitor 2是有效的DGAT-1抑制剂,具有减肥功效。

名称

• 中文名: 4-[4-(4-氨基-7,7-二甲基-7H-嘧啶并[4,5-B][1,4]噁唑-6-基)苯基]双环[2.2.2]辛烷-1-乙酸
• 英文名: 2-[4-[4-(4-amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-1-bicyclo[2.2.2]octanyl]acetic acid
• 中文别名: 4-[4-(4-氨基-7,7-二甲基-7H-嘧啶并[4,5-B][1,4]恶嗪-6-基)苯基]双环[2.2.2]辛烷-1-乙酸
• 英文别名: bicyclo[2.2.2]octane-pyrimido[4,5-b][1,4]oxazine deriv.,4; DGAT 1 inhibitor 2,DGAT1 inhibitor 2; 4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]Bicyclo[2.2.2]octane-1-acetic acid; DGAT1-IN-4; 7-dimethyl-7H-pyrimido[4; Bicyclo[2.2.2]octane-1-acetic acid; 5-b][1; DGAT-1 inhibitor 2||Bicyclo[2.2.2]octane-1-acetic acid,4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]; BICYCLO[2.2.2]OCTANE-1-ACETIC ACID, 4-[4-(4-AMINO-7,7-DIMETHYL-7H-PYRIMIDO[4,5-B][1,4]OXAZIN-6-YL)PHENYL]; DGAT-1 inhibitor 2, 10 mM in DMSO; CS-0982; 4-[4-(4-amino-7; Bicyclo[2.2.2]octane-1-acetic acid,4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]; 4]oxazin-6-yl)phenyl]; DGAT-1 INHIBITOR;BICYCLO[2.2.2]OCTANE-1-ACETIC ACID; 4-[4-(4-AMINO-7;7-DIMETHYL-7H-PYRIMIDO[4;5-B][1;4]OXAZIN-6-YL)PHENYL]

物化性质

• 分子式: C₂₄H₂₈N₄O₃
• 分子量: 420.50400
• 精确质量: 420.21600
• PSA: 110.69000
• LogP: 4.43410
• 储存条件: 2-8℃

生物活性

• 描述: DGAT-1 inhibitor 2是有效的DGAT-1抑制剂,具有减肥功效。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 酰基转移酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41.

  [2]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-15

  [3]. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents. Expert Opin Ther Pat. 2010 Jan;20(1):19-29.

  [4]. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.