74434-59-6

• 常用中文名：Sauvagine
• 常用英文名：Sauvagine TFA
• CAS号：74434-59-6
• 分子式：C₂₀₂H₃₄₆N₅₆O₆₃S
• 分子量：3334.68
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 CRFR
• 发布时间：2018-06-12 18:00:16
• 更新时间：2026-07-23 09:34:00
• Sauvagine,是一种来自青蛙皮肤的 40 个氨基酸的神经肽,是哺乳动物 CRF 激动剂。Sauvagine 可有效从大鼠垂体细胞释放 ACTH。Sauvagine 在利尿,心血管系统和内分泌腺体方面具有许多药理作用。

名称

• 中文名: 激动剂多肽SAUVAGINE, FROG
• 英文名: Sauvagine
• 中文别名: SAUVAGINE TFA,CRF 激动剂; 蛙皮降压肽; 神经肽SAUVAGINE, FROG
• 英文别名: H-PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-G-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-G-LEU-LEU-LEU-ASP-THR-ILE-NH2; Sauvagine >= (HPLC); pGlu-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; PGLU-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-G-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-G-LEU-LEU-LEU-ASP-THR-ILE-NH2; SAUVAGINE (FROG); Sauvagine trifluoroacetate salt; PYR-GPPISIDLSLELKMIEIEKQEKEKQQAANNRLLLDTI-NH2; C202H346N56O63S; PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-G-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-G-LEU-LEU-LEU-ASP-THR-ILE-NH2; GLP-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-G-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-G-LEU-LEU-LEU-ASP-THR-ILE-NH2; Pyr-GPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2

物化性质

• 分子式: C₂₀₂H₃₄₆N₅₆O₆₃S
• 分子量: 3334.68
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Sauvagine,是一种来自青蛙皮肤的 40 个氨基酸的神经肽,是哺乳动物 CRF 激动剂。Sauvagine 可有效从大鼠垂体细胞释放 ACTH。Sauvagine 在利尿,心血管系统和内分泌腺体方面具有许多药理作用。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. David A Lovejoy, et al. Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates. J Chem Neuroanat. 2013 Dec;54:50-6.

  [2]. P C Montecucchi, et al. Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei. Int J Pept Protein Res. 1981 Aug;18(2):113-20.

  [3]. M H Perrin, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport