974-23-2

• 常用中文名：16,17-环氧孕烯醇酮
• 常用英文名：16α,17α-Epoxy-3β-hydroxy-5-pregnen-20-one
• CAS号：974-23-2
• 分子式：C₂₁H₃₀O₃
• 分子量：330.461
• 相关类别： 化学试剂 有机试剂 脂肪酮(含烯醇)
• 发布时间：2018-12-27 17:40:02
• 更新时间：2026-07-01 04:53:07
• 【用途一】
  可的松醋酸酯、氢化可的松、己酸孕酮等的中间体。

名称

• 中文名: 16,17-alpha环氧孕烯醇酮
• 英文名: 16a,17-Epoxy-3b-hydroxypregn-5-en-20-one
• 中文别名: 17Α-环氧-3-羟基孕甾-5-烯-20-酮; 16Α,17Α-环氧-3-羟基孕甾-5-烯-20-酮,16Α,17Α-环氧孕甾-5-烯-3-醇-20-酮; 16,17Α-环氧孕烯醇酮; 氧桥物; 16,17-α环氧孕烯醇酮; 16α,17α-环氧-3-羟基孕甾-5-烯-20-酮; 16,17-ALPHA环氧孕烯醇酮; 16,17-ALPHA 环氧孕烯醇酮; 16A,17A-环氧-3B-羟基孕甾-5-烯-20-酮; 16α,17α-环氧孕甾-5-烯-3-醇-20-酮
• 英文别名: 16a,17-oxy-3b-hydroxypregn-5-en-20-one; 16-α,17-α-oxy-3-β-hydroxypregn-5-en-20-one; 3β-Hydroxy-16α,17α-epoxy-5-pregnen-20-one; 16α,17α-oxypregnenolone; (3β,16α)-3-Hydroxy-16,17-epoxypregn-5-en-20-one; 5-PREGNEN-16ALPHA,17ALPHA-OXY-3BETA-OL-20-ONE; 16a,17a-oxypregnenolone; 16-alpha,17-alpha-oxy-3-beta-hydroxypregn-5-en-20-one; Pregn-5-en-20-one, 16,17-oxy-3-hydroxy-, (3β,16α); 3BETA-HYDROXY-16ALPHA, 17ALPHA-OXY-DELTA5-PREGNEN-20-ONE; 3BETA-HYDROXY-16ALPHA,17ALPHA-OXY-5-PREGNEN-20-ONE; 1-((3S,8R,9S,10R,13S,14S,16R,17S)-3-HYDROXY-10,13-DIMETHYL-1,2,3,4,7,8,9,10,11,12,13,14,15,16-TETRADECAHYDRO-20-OXA-CYCLOPROPA[16,17]CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE; 16,17-oxypregn-5-en-3-ol-20-one; 16a,17a-oxy-3b-hydroxypregn-5-en-20-one; 16,17-ALPHA OXY PREGNENOLONE; 16,17α-oxyPregna-5-en-3-Hydroxy-20-one; 3β-Hydroxy-16α,17α-oxy-5-pregnen-20-one; 16,17-Epoxypregnenolone; 16,17-oxypregnenol; 5-PREGNEN-16, 17-OXY-3β-OL-20-ONE; 16,17-OXYPREGNENOLONE; 16,17α-oxy prognenolone; OXYPREGNENOLONE; EINECS 213-548-2; 5-PREGNEN-16,17-OXY-3-BETA-OL-20-ONE; 17α-oxy prognenolone; 16a,17-oxy-5-en-3b-Hydroxypregn-20-one; 16,17-ALPHA OXYPREGNENOLONE MIN; 16,17-oxy-3-hydroxypregn-5-en-20-one; 16,17a-oxypregnenolone; 3β-hydroxy-16α,17α-oxypregn-5-en-20-one; 16,17α-oxypregnenolone; Oxygen bridge; MFCD00135147; 16ALPHA,17ALPHA-OXYPREGNENOLONE

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 462.3±45.0 °C at 760 mmHg
• 分子式: C₂₁H₃₀O₃
• 分子量: 330.461
• 闪点: 159.4±22.2 °C
• 精确质量: 330.219482
• PSA: 49.83000
• LogP: 3.22
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.577
• 储存条件: −20°C

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

合成路线

979-02-2 ~94% 974-23-2

文献：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH Patent: WO2004/60906 A1, 2004 ; Location in patent: Page/Page column 6 ;

1162-53-4 ~97% 974-23-2

文献：Holland, Herbert L.; Riemland, Elly; Ulrich, Daum Canadian Journal of Chemistry, 1982 , vol. 60, p. 1919 - 1923

911442-53-0 ~% 974-23-2

文献：US2684364 , ; US2705233 , ; Journal of the Chemical Society, , p. 958,962

93-59-4 78792-99-1 ~% 974-23-2

文献：Journal of the American Chemical Society, , vol. 72, p. 367,369 US2686181 , ;

6996-36-7 ~% 974-23-2

文献：Journal of the American Chemical Society, , vol. 72, p. 367,369

67-56-1 ~% 974-23-2

文献：US2782193 , ;

上下游产品

上游产品  6
979-02-2 1162-53-4 93-59-4 78792-99-1
6996-36-7 67-56-1
下游产品  9
34209-81-9 387-79-1 21853-84-9 57-88-5
68-96-2 1044-90-2 1097-51-4 1162-53-4
14072-39-0

制备

【方法一】
可用薯蓣皂素经氧化、水解、消除、环氧化等叔反应制得该品。