| 英文名 | Rrd-251 hydrochloride |
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| 英文别名 |
MFCD01242444
2,4-Dichlorobenzyl carbamimidothioate hydrochloride (1:1) Rb/Raf-1 disruptor 251 hydrochloride S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride Rrd-251 hydrochloride 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride MFCD00035047 (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride Carbamimidothioic acid, (2,4-dichlorophenyl)methyl ester, hydrochloride (1:1) |
| 描述 | RRD-251盐酸盐是Rb/Raf-1相互作用的小分子破坏剂,有效和选择性地破坏Rb/Raf-1(IC50=77 nM),但不破坏Rb/E2F,Rb/抑制素,Rb/细胞周期蛋白E和Rb/HDAC结合；抑制Rb将Raf-1募集到增殖启动子并抑制E2F1依赖性转录活性；抑制人癌细胞的锚定依赖性和锚定非依赖性生长；显着抑制体内具有功能性Rb的肿瘤中的肿瘤生长。 |
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| 参考文献 | References 1. Kinkade R, et al. Cancer Res. 2008 May 15;68(10):3810-8. 2. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41. 3. Treviño JG, et al. Mol Cancer Ther. 2013 Dec;12(12):2722-34. 4. Wallace AS, et al. Oncotarget. 2016 Jul 19;7(29):46401-46418. View Related Products by Target Raf |
| 分子式 | C8H8Cl2N2S |
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| 分子量 | 271.595 |
| 精确质量 | 269.955200 |
