131916-62-6

131916-62-6 structure

Name: RRD-251
Chemical Name: Rrd-251 hydrochloride
CAS Number: 131916-62-6
Molecular Formula: C₈H₈Cl₂N₂S
Molecular Weight: 271.595
Create Date: 2020-01-12 07:15:51
Modify Date: 2024-01-04 16:08:29
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding; inhibits Rb to recruit Raf-1 to proliferative promoters and inhibited E2F1-dependent transcriptional activity; inhibits anchorage-dependent and anchorage-independent growth of human cancer cells; significantly inhibits tumor growth in tumors with functional Rb in vivo.

Name	Rrd-251 hydrochloride
Synonyms	MFCD01242444 2,4-Dichlorobenzyl carbamimidothioate hydrochloride (1:1) Rb/Raf-1 disruptor 251 hydrochloride S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride Rrd-251 hydrochloride 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride MFCD00035047 (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride Carbamimidothioic acid, (2,4-dichlorophenyl)methyl ester, hydrochloride (1:1)

Description	RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding; inhibits Rb to recruit Raf-1 to proliferative promoters and inhibited E2F1-dependent transcriptional activity; inhibits anchorage-dependent and anchorage-independent growth of human cancer cells; significantly inhibits tumor growth in tumors with functional Rb in vivo.
References	References 1. Kinkade R, et al. Cancer Res. 2008 May 15;68(10):3810-8. 2. Singh S, et al. Mol Cancer Ther. 2010 Dec;9(12):3330-41. 3. Treviño JG, et al. Mol Cancer Ther. 2013 Dec;12(12):2722-34. 4. Wallace AS, et al. Oncotarget. 2016 Jul 19;7(29):46401-46418. View Related Products by Target Raf