1785666-54-7
1785666-54-7结构式
- 常用中文名：FK-866 Hydrochloride
- 常用英文名：FK-866 Hydrochloride
- CAS号：1785666-54-7
- 分子式：C24H30ClN3O2
- 分子量：427.967
- 发布时间：2021-01-10 13:20:22
- 更新时间：2024-04-05 15:57:53
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Daporinad, also known as APO-866 and FK866, is a small molecule with potential antineoplastic and antiangiogenic activities. NMPRTase inhibitor APO866 binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell prioduction of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis.
| 英文名 | (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)acrylamide hydrochloride (1:1) |
|---|---|
| 英文别名 |
(2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)acrylamide hydrochloride (1:1)
2-Propenamide, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-, (2E)-, hydrochloride (1:1) MFCD10565943 |
| 分子式 | C24H30ClN3O2 |
|---|---|
| 分子量 | 427.967 |
| 精确质量 | 427.202667 |