154127-42-1

• 常用中文名：(S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺酰胺 1,1-二氧化物
• 常用英文名：(S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
• CAS号：154127-42-1
• 分子式：C₁₀H₁₆N₂O₆S₃
• 分子量：356.43900
• 发布时间：2018-11-27 21:02:14
• 更新时间：2026-07-13 13:06:10

名称

• 中文名: (S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺酰胺 1,1-二氧化物
• 英文名: (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
• 中文别名: 布林佐胺中间体(N-2); 布林中间体; 布林佐胺中间体154-1; (S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-e]-1,2-噻嗪-6-磺酰胺 1,1-二氧化物; 布林佐胺杂质14; 3,4-二氢-4-羟基-2-(3-甲氧基丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺酰胺; (S)-4-羟基-2-(3-甲氧丙基)-3,4-二氢-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺酰胺-1,1-二氧化物; 溴苯甲酰胺杂质5; (S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺酰胺1,1-二氧化; 布林左胺SM杂质; (S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-e]-1,2-噻嗪-6-磺酰胺 1,1-二; (S)-4-羟基-2-(3-甲氧基丙基)-3,4-二氢-2H-噻吩并-[3,2-E][1,2]噻嗪-6-磺酰胺 1,1-二氧; 布林佐胺相关化合物A; (S)-4-羟基-2-(3-甲氧基丙基)-3,4-二氢-2H-噻吩并[3,2-E] [1,2]噻嗪-6-磺酰胺1,1-二氧化物; (S)-3,4-二氢-4-羟基-2-(3-甲氧基丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺胺-1,1-二氧化物; 布林佐胺杂质5; 化合物 (S)-4-HYDROXY-2-(3-METHOXYPROPYL)-3,4-DIHYDRO-2H-THIENO[3,2-E][1,2]THIAZINE-6-SULFONAMIDE 1,1-DIOXIDE; 布林佐胺中间体（n-2）; S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6-磺酰胺 1,1-二氧化物布林佐胺中间体; 布林唑胺杂质I; (S)-3,4-二氢-4-羟基-2-(3-甲氧丙基)-2H-噻吩并[3,2-E]-1,2-噻嗪-6; 布林佐胺相关物质A
• 英文别名: (4S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno; 3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; (4S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; Brinzolamide Impurity 5; (4R)-4-(Isopropylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide; (4S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxi; Brinzolamide (4S)-Hydroxy Analog; (S)-4-Hydroxy-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonaMide 1,1-dioxide; 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, (4S)- (9CI, ACI); (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide; sulfonamide 1,1-dioxide; (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-###154-1; 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide,3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide; 4-hydroxy-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonaMide 1,1-dioxide; Brinzolamide Intermediate 1; (S)-3,4-Dihydro-4-hydroxy-2-(3-Methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonaMide-1,1-dioxid; BrinzolaMide Related CoMpound A; (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2; (S)-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-4-ol-6-sulfonaMide-1,1- dioxide; Brinzolamide Impurity I; 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide (4S)- (9CI ACI); (4R)-4-(Isopropylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; 4-Hydroxy-2-(3-methoxypropyl); (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno-[3,2-e][1,2]thiazine-6-sulfonamide 1,1-di; (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1; (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2; (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide; (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno-[3,2-e][1,2]thiazine-6-sulfonamide 1,1; (4S)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonaMide,3,4-dihydro-4-hydroxy-2-(3-Methoxypropyl)-, 1,1-dioxide, (4S); (4S) -1, 1-dioxide-3, 4-dihydro-4-hydroxy-2 - (4S) -1, 1-dioxide-3, 4-dihydro-4-hydroxy-2

物化性质

• 密度: 1.575 g/cm3
• 沸点: 612.4ºC at 760 mmHg
• 分子式: C₁₀H₁₆N₂O₆S₃
• 分子量: 356.43900
• 闪点: 324.2ºC
• 精确质量: 356.01700
• PSA: 172.00000
• LogP: 2.26950
• 蒸汽压: 7.49E-16mmHg at 25°C
• 折射率: 1.615
• 储存条件: 2~8℃，干燥，密封

安全

• 危害码 (欧洲): Xi
• 海关编码: 2935009090

合成路线

1245550-91-7 ~64% 154127-42-1

文献：AZAD PHARMACEUTICAL INGREDIENTS AG; RAMAKRISHNAN, Arul; SONI, Anil Kumar; ADHIKARI, Sujit Das; RAO, Kommula Srinivasa; PAUL, Soumendu; SRINIVASULU, Ganta Patent: WO2010/103115 A1, 2010 ; Location in patent: Page/Page column 15-16 ;

154127-41-0 111-42-2 ~89% 154127-42-1

文献：Alcon Laboratories, Inc. Patent: US5378703 A1, 1995 ;

36157-40-1 ~% 154127-42-1

文献：Organic Process Research and Development, , vol. 3, # 2 p. 114 - 120

1029324-91-1 ~59% 154127-42-1

文献：Sathe, Dhananjay Govind; Tarur, Radhakrishnan Venkatasubramanian; Bhise, Nandu Baban; Shinde, Ajit Bhaskar; Pardeshi, Santosh Patent: US2010/9977 A1, 2010 ; Location in patent: Page/Page column 11 ;

160982-13-8 ~61% 154127-42-1

文献：Conrow, Raymond E.; Dean, W. Dennis; Zinke, Paul W.; Deason, Michael E.; Sproull, Steven J.; Dantanarayana, Anura P.; DuPriest, Mark T. Organic Process Research and Development, 1999 , vol. 3, # 2 p. 114 - 120

160982-09-2 ~% 154127-42-1

文献：Organic Process Research and Development, , vol. 3, # 2 p. 114 - 120

上下游产品

上游产品  6
1029324-91-1 160982-13-8 154127-41-0 111-42-2
36157-40-1 160982-09-2
下游产品  1
138890-62-7

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%