122860-33-7

• 常用中文名：N-CBZ-4-哌啶甲醇(1-CBZ-4-羟甲基哌啶)
• 常用英文名：1-Cbz-4-Hydroxymethylpiperidine
• CAS号：122860-33-7
• 分子式：C₁₄H₁₉NO₃
• 分子量：249.306
• 发布时间：2018-08-23 12:50:31
• 更新时间：2024-01-02 17:21:57

名称

• 中文名: N-Cbz-4-羟甲基哌啶
• 英文名: N-Cbz-4-(hydroxymethyl)piperidine
• 中文别名: N-CBZ-4-哌啶甲醇; 1-Cbz-4-羟甲基哌啶; N-苄氧羰基-4-哌啶甲醇
• 英文别名: 1-Cbz-4-Hydroxymethylpiperidine; Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate; Benzyl 4-(hydroxymethyl)-1-piperidinecarboxylate; Benzyl-4-(hydroxymethyl)piperidin-1-carboxylat; 1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, phenylmethyl ester; N-Cbz-4-hydroxymethylpiperidine; MFCD02094490; 1-Cbz-4-hydroxy methyl piperidine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 396.4±25.0 °C at 760 mmHg
• 分子式: C₁₄H₁₉NO₃
• 分子量: 249.306
• 闪点: 193.5±23.2 °C
• 精确质量: 249.136490
• PSA: 49.77000
• LogP: 1.50
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.550
• 储存条件: 室温，干燥

MSDS

Name: Benzyl 4-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate 95+% Material Safety Data Sheet Synonym: 4-Hydroxymethylpiperidine-1-carboxylic acid benzyl este CAS: 122860-33-7 Section 1 - Chemical Product MSDS Name:Benzyl 4-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate 95+% Material Safety Data Sheet Synonym:4-Hydroxymethylpiperidine-1-carboxylic acid benzyl este Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 122860-33-7 Benzyl 4-(hydroxymethyl)tetrahydro-1(2 95+% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 122860-33-7: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Viscous liquid Color: yellow Odor: pleasant odor pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Specific Gravity/Density: Molecular Formula: C14H19NO3 Molecular Weight: 249 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents, acid chlorides. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, acrid smoke and fumes. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 122860-33-7 unlisted. LD50/LC50: Not available. Carcinogenicity: Benzyl 4-(hydroxymethyl)tetrahydro-1(2H)-pyridinecarboxylate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 122860-33-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 122860-33-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 122860-33-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36/37/39-37/39
• 海关编码: 2933399090

合成路线

6457-49-4 501-53-1 ~90% 122860-33-7

文献：INSTITUT PASTEUR KOREA; KIM, Junwon; CECHETTO, Jonathan; NO, Zaesung; CHRISTOPHE, Thierry; KIM, Taehee; NAM, Ji, Youn; SO, Wonyoung; JO, Mina; OK, Taedong; PARK, Changmin; SEO, Min, Jung; SOHN, Jeong-Hun; SOMMER, Peter; BOESE, Annette, Sophia; HAN, Sung-Jun; PARK, Young, Sam; KIM, Hwa, Pyung Patent: WO2010/46780 A2, 2010 ; Location in patent: Page/Page column 63-64 ;

6457-49-4 1885-14-9 ~44% 122860-33-7

文献：SmithKline Beecham plc Patent: EP1051413 B1, 2003 ;

501-53-1 ~45% 122860-33-7

文献：Fang, Xinqin; Garvey, David S.; Gaston, Ricky D.; Lin, Chia-En; Ranatunga, Ramani R.; Richardson, Stewart K.; Wang, Tiansheng; Wang, Weiheng; Wey, Shiow-Jyi Patent: US2003/203915 A1, 2003 ;

622-26-4 501-53-1 ~91% 122860-33-7

文献：Sterling Winthrop Inc. Patent: US5512589 A1, 1996 ; US 5512589 A

10314-98-4 ~% 122860-33-7

文献：Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3586 - 3604

6457-49-4 31139-36-3 ~% 122860-33-7

文献：US4968704 A1, ;

498-94-2 ~% 122860-33-7

文献：Chinese Chemical Letters, , vol. 23, # 6 p. 661 - 664

160809-38-1 ~85% 122860-33-7

文献：NEUROSEARCH A/S Patent: WO2007/93603 A1, 2007 ; Location in patent: Page/Page column 15 ; WO 2007/093603 A1

1126-09-6 ~% 122860-33-7

文献：Tetrahedron Letters, , vol. 48, # 2 p. 199 - 202

上下游产品

上游产品  9
6457-49-4 501-53-1 160809-38-1 1885-14-9
622-26-4 10314-98-4 31139-36-3 1126-09-6
498-94-2
下游产品  8
149897-41-6 160586-68-5 138163-08-3 159275-16-8
159275-17-9 178261-41-1 167484-18-6 922504-27-6

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%