188576-49-0

• 常用中文名：叔丁基 7-羟基-3,4-二氢异喹啉-2(1H)-甲酸酯
• 常用英文名：TERT-BUTYL 7-HYDROXY-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
• CAS号：188576-49-0
• 分子式：C₁₄H₁₉NO₃
• 分子量：249.30600
• 发布时间：2018-12-23 12:40:42
• 更新时间：2025-08-27 13:13:41

名称

• 中文名: 7-羟基-3,4-二氢异喹啉-2(1h)-羧酸叔丁酯
• 英文名: tert-butyl 7-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
• 中文别名: 叔丁基 7-羟基-3,4-二氢异喹啉-2(1H)-甲酸酯
• 英文别名: 7-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; tert-butyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; N-boc 1,2,3,4-Tetrahydro-isoquinolin-7-ol; 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; N-Boc-7-hydroxy-3,4-dihydro-1H-isoquinoline; 2-tert-butoxycarbonyl-7-hydroxy-1,2,3,4-tetrahydroisoquinoline

物化性质

• 密度: 1.171g/cm3
• 沸点: 391.376ºC at 760 mmHg
• 分子式: C₁₄H₁₉NO₃
• 分子量: 249.30600
• 闪点: 190.497ºC
• 精确质量: 249.13600
• PSA: 49.77000
• LogP: 2.62330
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.558
• 储存条件: 2-8°C， 干燥

安全

• 海关编码: 2933499090

合成路线

30798-64-2 24424-99-5 ~93% 188576-49-0

文献：Middleton, Donald S.; Maw, Graham N.; Challenger, Clare; Jessiman, Alan; Johnson, Patrick S.; Million, William A.; Nichols, Carly L.; Price, Jenny A.; Trevethick, Michael Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 905 - 910

188576-56-9 24424-99-5 ~73% 188576-49-0

文献：Ajinomoto Co., Inc. Patent: EP2311810 A1, 2011 ; Location in patent: Page/Page column 20 ;

39989-39-4 ~% 188576-49-0

文献：Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189

7651-83-4 ~% 188576-49-0

文献：Ajinomoto Co., Inc. Patent: EP2311810 A1, 2011 ;

24424-99-5 110192-19-3 ~% 188576-49-0

文献：Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Hase, Yasunori; Uchida, Itsuo; Aisaka, Kazuo; Katoh, Susumu; Cho, Hidetsura Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3586 - 3604

1700-37-4 ~% 188576-49-0

文献：Kucznierz, Ralf; Grams, Frank; Leinert, Herbert; Marzenell, Klaus; Engh, Richard A.; Von der Saal, Wolfgang Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4983 - 4994

123-91-1 24424-99-5 110192-19-3 ~% 188576-49-0

文献：Japan Tobacco Inc. Patent: US6562828 B1, 2003 ; US 6562828 B1

43207-78-9 ~% 188576-49-0

文献：Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189

591-31-1 ~% 188576-49-0

文献：Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Uchida, Itsuo; Aisaka, Kazuo; Hase, Yasunori; Katoh, Susumu; Cho, Hidetsura Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 185 - 189

上下游产品

上游产品  10
30798-64-2 24424-99-5 188576-56-9 39989-39-4
7651-83-4 110192-19-3 1700-37-4 123-91-1
43207-78-9 591-31-1
下游产品  1
158984-83-9

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%