毒理学数据:
1.急性毒性
LD50:5170mg/kg(大鼠经口);7600mg/kg(兔经皮)
LC50:46000mg/m3(大鼠吸入,2h)
2.刺激性
家兔经皮:515mg,轻度刺激(开放性刺激试验)
家兔经眼:100mg,重度刺激。
3.亚急性与慢性毒性 大鼠接触浓度为10.6g/m3,每天8h,4~26次,10只动物中有7只死亡,存活动物出现黏膜刺激、消瘦、痉挛、麻醉、蛋白尿及严重肝肾损害。
4.致突变性 DNA抑制:人HeLa细胞400mmol/L。DNA损伤:大鼠经口2550mg/kg。微核试验:小鼠经口900mg/kg。姐妹染色单体交换:仓鼠卵巢10500mg/L。
5.致畸性 大鼠孕后6~15d经口给予最低中毒剂量(TDLo)10g/kg,致肌肉骨骼系统发育畸形
6.致癌性 IARC致癌性评论:G2B,可疑人类致癌物。
生态学数据:
1.生态毒性
LC50:10000ppm(96h)(蓝鳃太阳鱼,静态);13000mg/L(96h)(黑头呆鱼,静态)
EC50:4700mg/L(24h)(水蚤)
2.生物降解性
好氧生物降解(h):672~4320
厌氧生物降解(h):2688~17280
3.非生物降解性
水中光氧化半衰期(h):1608~8.00×104
空气中光氧化半衰期(h):8.1~81
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
JG8225000
-
CHEMICAL NAME :
-
p-Dioxane
-
CAS REGISTRY NUMBER :
-
123-91-1
-
BEILSTEIN REFERENCE NO. :
-
0102551
-
LAST UPDATED :
-
199712
-
DATA ITEMS CITED :
-
88
-
MOLECULAR FORMULA :
-
C4-H8-O2
-
MOLECULAR WEIGHT :
-
88.12
-
WISWESSER LINE NOTATION :
-
T6O DOTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Human
-
TYPE OF TEST :
-
Open irritation test
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
470 ppm
-
TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold Vascular - BP elevation not characterized in autonomic section Gastrointestinal - other changes
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
5500 ppm/1M
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes
-
TYPE OF TEST :
-
LCLo - Lowest published lethal concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Human
-
DOSE/DURATION :
-
470 ppm/3D
-
TOXIC EFFECTS :
-
Brain and Coverings - other degenerative changes Lungs, Thorax, or Respiration - other changes Liver - other changes
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
7120 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
46 gm/m3/2H
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
799 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
5300 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
37 gm/m3/2H
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
790 mg/kg
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - cat
-
DOSE/DURATION :
-
2 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LCLo - Lowest published lethal concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Mammal - cat
-
DOSE/DURATION :
-
44 gm/m3/7H
-
TOXIC EFFECTS :
-
Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - cat
-
DOSE/DURATION :
-
1500 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - irritability
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
2 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
7600 uL/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
1500 mg/kg
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
3150 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
-
TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Mammal - species unspecified
-
DOSE/DURATION :
-
20500 mg/m3
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
6000 ppm/4H/2W-I
-
TOXIC EFFECTS :
-
Behavioral - changes in psychophysiological tests
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
20500 ug/m3/13W-I
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - changes in chlorine Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
185 gm/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
111 ppm/7H/2Y-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - tumors Blood - lymphoma, including Hodgkin's disease
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
239 gm/kg/90W-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
14 gm/kg/60W-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
12 gm/kg/8W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
416 gm/kg/57W-C
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
408 gm/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
523 gm/kg/90W-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
416 gm/kg/57W-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
528 gm/kg/63W-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
10 gm/kg
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
DNA damage
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Micronucleus test
MUTATION DATA
-
TYPE OF TEST :
-
Sister chromatid exchange
-
TEST SYSTEM :
-
Rodent - hamster Ovary
-
REFERENCE :
-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 90 mg/m3 (25 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 11,247,1976 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,201,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,201,1987 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 TOXICOLOGY REVIEW ECIET* European Chemical Industry Ecology and Toxicology Centre. Joint Assessment of Commodity Chemicals. (Avenue Louise 250, B-63, B-1050 Brussels, Belgium) Volume(issue)/page/year: (2),-,1983 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (360 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,94,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (360 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (360 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (360 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (360 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 25 ppm (90 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 50 ppm (180 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 25 ppm (90 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 10 ppm (36 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (90 mg/m3);STEL 40 ppm (135 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (35 mg/m3);STEL 40 ppm (140 mg/m3);Carcinogen JAN 1993 OEL-GERMANY:TWA 50 ppm (180 mg/m3);Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 10 ppm (36 mg/m3);Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (180 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (360 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:TWA 10 ppm;STEL 10 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 25 ppm (90 mg/m3);STEL 50 ppm;Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 25 ppm (90 mg/m3);STEL 50 ppm;Skin JAN 1993 OEL-TURKEY:TWA 100 ppm (360 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 25 ppm (90 mg/m3);STEL 100 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIOXANE-air:CA CL 1 ppm/30M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 25145 No. of Facilities: 12911 (estimated) No. of Industries: 135 No. of Occupations: 101 No. of Employees: 147783 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 25145 No. of Facilities: 20994 (estimated) No. of Industries: 181 No. of Occupations: 137 No. of Employees: 429330 (estimated) No. of Female Employees: 149697 (estimated)
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